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Frequency, underdiagnosis, and heterogeneity of epidermal growth factor receptor exon 20 insertion mutations using real-world genomic datasets.

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第一作者： Santiago,Viteri

第一单位： UOMI Cancer Center, Clínica Mi Tres Torres, Barcelona, Spain.

作者： Santiago,Viteri ^[1] ; Anna,Minchom ^[2] ; Lyudmila,Bazhenova ^[3] ; Sai-Hong Ignatius,Ou ^[4] ; Joshua M,Bauml ^[5] ; Scott A,Shell ^[6] ; Michael,Schaffer ^[7] ; Junchen,Gu ^[7] ; Jennifer B,Rose ^[7] ; Joshua C,Curtin ^[7] ; Parthiv,Mahadevia ^[7] ; Nicolas,Girard ^[8]

作者单位： UOMI Cancer Center, Clínica Mi Tres Torres, Barcelona, Spain. ^[1] Drug Development Unit, Royal Marsden/Institute of Cancer Research, Sutton, UK. ^[2] University of California San Diego, CA, USA. ^[3] Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Orange, CA, USA. ^[4] Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. ^[5] Guardant Health, Redwood City, CA, USA. ^[6] Janssen R&D, Spring House, PA, USA. ^[7] Institut Curie, Institut du Thorax Curie-Montsouris, Paris, France. ^[8]

关键词 EGFR Exon 20 insertion mutations NGS NSCLC PCR

医学主题词人类(Humans);肺肿瘤(Lung Neoplasms);诱变, 插入(Mutagenesis, Insertional);突变(Mutation);外显子(Exons);基因组学(Genomics);蛋白激酶抑制剂(Protein Kinase Inhibitors)

DOI 10.1002/1878-0261.13327

PMID 36269676

发布时间 2023-11-06

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准确一般字义偏差语意偏离译文作用小提交