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A path to translation: How 3D patient tumor avatars enable next generation precision oncology.

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作者单位: Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27708, USA. [1] Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY 12208, USA. [2] Department of Medicine, Washington University in St. Louis, St. Louis, MO, 63110 USA. [3] Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Uppsalalaan 8, Utrecht, 3584 CT, Netherlands; Research and Early Development (pRED) of F. Hoffmann-La Roche Ltd, Roche Pharma, Basel, Switzerland. [4] Vall d'Hebron Hospital Campus and Institute of Oncology, International Oncology Bureau-Quiron, University of Vic-Central University of Catalonia, Barcelona, 08035 Spain. [5] Department of Medicine, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. [6] The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. [7] Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA. [8] Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. [9] Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27708, USA. [10] The Wistar Institute, Philadelphia, PA 19104, USA. [11] Department of Biomedical Engineering and the Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22903, USA. [12] The Jackson Laboratory, Bar Harbor, ME 04660, USA. [13] European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. [14] Departments of Pathology and Internal Medicine (Medical Oncology), Yale School of Medicine and Yale Cancer Center, New Haven, CT 06510, USA. [15] Department of Computer Science, Princeton University, Princeton, NJ 08540, USA. [16] The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT 06032, USA; Institute for Systems Genomics, University of Connecticut, Farmington, CT 06032, USA. [17] Department of Medical and Molecular Genetics, Oregon Health & Science University, Portland, OR 97201, USA. [18] Lustgarten Foundation Pancreatic Cancer Research Laboratory at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. [19] Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. [20] Department of Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. [21] Department of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA. [22] Division of Cancer Biology, National Cancer Institute, NIH, Rockville, MD 20850, USA. Electronic address: salnikok@mail.nih.gov. [23] The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT 06032, USA; Institute for Systems Genomics, University of Connecticut, Farmington, CT 06032, USA. Electronic address: jeff.chuang@jax.org. [24] Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA. Electronic address: xiling.shen@terasaki.org. [25]
DOI 10.1016/j.ccell.2022.09.017
PMID 36270276
发布时间 2024-12-13
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