Formation of toxic oligomers of polyQ-expanded Huntingtin by prion-mediated cross-seeding.

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第一作者： Michael H M,Gropp

第一单位： Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

作者： Michael H M,Gropp ^[1] ; Courtney L,Klaips ^[2] ; F Ulrich,Hartl ^[3]

作者单位： Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany. ^[1] Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany; Department of Biomedical Sciences of Cells & Systems, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, the Netherlands. Electronic address: c.l.klaips@umcg.nl. ^[2] Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address: uhartl@biochem.mpg.de. ^[3]

关键词 Huntington’s disease Rnq1 cross-seeding neurodegeneration oligomers optogenetics polyQ prion protein aggregation proteostasis

主题词人类(Humans);朊病毒(Prions);酿酒酵母蛋白质类(Saccharomyces cerevisiae Proteins);酿酒酵母菌(Saccharomyces cerevisiae);肽类(Peptides)

DOI 10.1016/j.molcel.2022.09.031

PMID 36272412

发布时间 2023-01-09

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