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Case report: Senescence as mechanism of resistance to Pembrolizumab in a Lymphoma patient who failed CD19-Targeted CAR-T cell therapy.

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第一作者： Serena,De Matteis

第一单位： IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

作者： Serena,De Matteis ^[1] ; Beatrice,Casadei ^[2] ; Ginevra,Lolli ^[2] ; Michele,Dicataldo ^[2] ; Francesco,Barbato ^[2] ; Elisa,Dan ^[3] ; Andrea,Paccagnella ^[3] ; Barbara,Sinigaglia ^[3] ; Clara,Bertuzzi ^[1] ; Annalisa,Arcari ^[4] ; Luca,Zazzeroni ^[3] ; Patrizia,Bernuzzi ^[4] ; Noemi,Laprovitera ^[1] ; Gianluca,Storci ^[1] ; Salvatore Nicola,Bertuccio ^[5] ; Manuela,Ferracin ^[3] ; Massimiliano,Bonafè ^[3] ; Pier Luigi,Zinzani ^[2] ; Francesca,Bonifazi ^[1]

作者单位： IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. ^[1] IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.;Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy. ^[2] Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy. ^[3] Hematology and Bone Marrow Transplant Unit, "Guglielmo da Saliceto" Hospital, Piacenza, Italy. ^[4] Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. ^[5]

关键词 chimeric antigen receptor (CAR T)exhaustion lymphoma pembrolizumab resistance senescence

医学主题词人类(Humans);抗原, CD19(Antigens, CD19);免疫疗法, 过继(Immunotherapy, Adoptive);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);淋巴瘤, 大B细胞, 弥漫性(Lymphoma, Large B-Cell, Diffuse)

DOI 10.3389/fimmu.2022.994731

PMID 36275688

发布时间 2022-10-26

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