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Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology.

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第一作者： Konstantinos,Lontos

第一单位： Tumor Microenvironment Center, Department of Immunology, UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA.;Division of Hematology/Oncology, UPMC, Pittsburgh, PA, USA.

作者： Konstantinos,Lontos ^[1] ; Yiyang,Wang ^[2] ; Mason,Colbert ^[3] ; Alok,Kumar ^[3] ; Supriya,Joshi ^[3] ; Mary,Philbin ^[3] ; Yupeng,Wang ^[4] ; Andrew,Frisch ^[5] ; Jason,Lohmueller ^[6] ; Dayana B,Rivadeneira ^[3] ; Greg M,Delgoffe ^[3]

作者单位： Tumor Microenvironment Center, Department of Immunology, UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA.;Division of Hematology/Oncology, UPMC, Pittsburgh, PA, USA. ^[1] School of Medicine, Tsinghua University, Beijing, Peking, China. ^[2] Tumor Microenvironment Center, Department of Immunology, UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA. ^[3] Tumor Microenvironment Center, Department of Immunology, UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA.;School of Medicine, Tsinghua University, Beijing, Peking, China. ^[4] Tumor Microenvironment Center, Department of Immunology, UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA.;Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. ^[5] Department of Surgery, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. ^[6]

关键词 AML B16 CD105 CAR-T cell acute myeloid leukemia cd105 immunocompetent CAR-T murine CAR-T cell

主题词动物(Animals);人类(Humans);小鼠(Mice);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);T淋巴细胞(T-Lymphocytes);转化生长因子β(Transforming Growth Factor beta)

DOI 10.1080/2162402X.2022.2131229

PMID 36275862

发布时间 2024-10-11

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