Antileukemic activity of YPN-005, a CDK7 inhibitor, inducing apoptosis through c-MYC and FLT3 suppression in acute myeloid leukemia.

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第一作者： Bon-Kwan,Koo

第一单位： Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

作者： Bon-Kwan,Koo ^[1] ; Eun-Ji,Choi ^[1] ; Eun-Hye,Hur ^[1] ; Ju Hyun,Moon ^[1] ; Ji Yun,Kim ^[1] ; Han-Seung,Park ^[1] ; Yunsuk,Choi ^[1] ; Jung-Hee,Lee ^[1] ; Kyoo-Hyung,Lee ^[1] ; Eun Kyung,Choi ^[2] ; Jinhwan,Kim ^[3] ; Je-Hwan,Lee ^[1]

作者单位： Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. ^[1] Asan Preclinical Evaluation Center for Cancer Therapeutics, Asan Medical Center, Seoul, South Korea. ^[2] R&D Institute, Yungjin Pharmaceutical Co., Ltd, South Korea. ^[3]

关键词 Acute myeloid leukemia (AML)Cyclin dependent kinase 7 (CDK7) inhibitor FLT3 MCL1 c-MYC

DOI 10.1016/j.heliyon.2022.e11004

PMID 36276757

发布时间 2022-10-25

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Heliyon

2022年8卷10期

e11004页

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Antileukemic activity of YPN-005, a CDK7 inhibitor, inducing apoptosis through c-MYC and FLT3 suppression in acute myeloid leukemia.

Heliyon

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Antileukemic activity of YPN-005, a CDK7 inhibitor, inducing apoptosis through c-MYC and FLT3 suppression in acute myeloid leukemia.

Heliyon

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Heliyon

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