Characterization of Ultrapotent Chemogenetic Ligands for Research Applications in Nonhuman Primates.

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作者： Jessica,Raper ^[1] ; Mark A G,Eldridge ^[2] ; Scott M,Sternson ^[3] ; Jalene Y,Shim ^[4] ; Grace P,Fomani ^[2] ; Barry J,Richmond ^[2] ; Thomas,Wichmann ^[2] ; Adriana,Galvan ^[1]

作者单位： Emory National Primate Research Center, Emory University, Atlanta, Georgia 30329, United States. ^[1] Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, United States. ^[2] Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, United States. ^[3] Department of Neurosciences, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093, United States. ^[4] Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, United States. ^[5] Morris K. Udall Center of Excellence for Parkinson's Disease, Emory University, Atlanta, Georgia 30322, United States. ^[6]

关键词 chemogenetics ligand-gated ion channels pharmacokinetics rhesus macaque uPSEMs varenicline

主题词动物(Animals);配体(Ligands);猕猴(Macaca mulatta);神经元(Neurons);脑(Brain)

DOI 10.1021/acschemneuro.2c00525

PMID 36279419

发布时间 2024-06-07

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