Metformin suppresses Oxidative Stress induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis.

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作者： Bohao,Chen ^[1] ; Qi,He ^[1] ; Junzheng,Yang ^[1] ; Zhaofeng,Pan ^[1] ; Jiacong,Xiao ^[1] ; Weijian,Chen ^[2] ; Weijin,Chi ^[1] ; Miao,Li ^[1] ; Shaocong,Li ^[1] ; Jiaxu,Zeng ^[1] ; Chuyi,Chen ^[1] ; FanChen,Wang ^[1] ; Xinyuan,Pang ^[3] ; Yanzi,Yi ^[4] ; Haitao,Tu ^[5] ; Haibin,Wang ^[6] ; Peng,Chen ^[7]

作者单位： 1st School of Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, Guangzhou 510405, PR China; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China. ^[1] Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China. ^[2] Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China. ^[3] The Third Affiliated Medical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China. ^[4] Department of Orthopaedics, First Affiliated Hospital, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, Guangzhou 510405, China. ^[5] Department of Orthopaedics, First Affiliated Hospital, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, Guangzhou 510405, China. Electronic address: whb@gzucm.edu.cn. ^[6] Department of Orthopaedics, First Affiliated Hospital, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, Guangzhou 510405, China. Electronic address: chenpeng5229@gzucm.edu.cn. ^[7]

关键词 Metformin Nrf2/HO-1 signaling pathway Oxidative stress Type 2 diabetic osteoporosis