Design, synthesis, and in vitro evaluation of novel antifungal triazoles containing substituted 1,2,3-triazole-methoxyl side chains.

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作者： Fei,Xie ^[1] ; Yumeng,Hao ^[1] ; Junhe,Bao ^[1] ; Jiacun,Liu ^[2] ; Yu,Liu ^[2] ; Ruina,Wang ^[2] ; Xiaochen,Chi ^[3] ; Xiaoyun,Chai ^[1] ; Ting,Wang ^[1] ; Shichong,Yu ^[1] ; Yongsheng,Jin ^[1] ; Lan,Yan ^[4] ; Dazhi,Zhang ^[5] ; Tingjunhong,Ni ^[6]

作者单位： Department of Organic Chemistry, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai 200433, China. ^[1] Center of New Drug Research, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai 200433, China. ^[2] School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China. ^[3] Center of New Drug Research, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai 200433, China. Electronic address: ylansmmu@sina.com. ^[4] Department of Organic Chemistry, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai 200433, China. Electronic address: zdzhang_yjhx@smmu.edu.cn. ^[5] Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No.1239 Siping Road, Shanghai 200072, China. Electronic address: ntjh860415@126.com. ^[6]

关键词 Antifungal activity CYP51 Structure-activity relationships Triazole derivatives

主题词人类(Humans);抗真菌药(Antifungal Agents);三唑类(Triazoles);微生物敏感性试验(Microbial Sensitivity Tests);氟康唑(Fluconazole);白色念珠菌(Candida albicans);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bioorg.2022.106216

PMID 36283177

发布时间 2022-11-12

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