Longitudinal Serum Protein Analysis of Women with a High Risk of Developing Breast Cancer Reveals Large Interpatient Versus Small Intrapatient Variations: First Results from the TESTBREAST Study.

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第一作者： Sophie C,Hagenaars

第一单位： Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

作者： Sophie C,Hagenaars ^[1] ; Lennard J M,Dekker ^[2] ; Bob,Ravesteijn ^[2] ; Ronald L P,van Vlierberghe ^[1] ; Fred P H T M,Romijn ^[3] ; Linda,Verhoeff ^[1] ; Arjen J,Witkamp ^[4] ; Karin E,Schenk ^[5] ; Kristien B I M,Keymeulen ^[6] ; Marian B E,Menke-Pluijmers ^[7] ; Anneriet E,Dassen ^[8] ; Birgitta A,Kortmann ^[9] ; Jakob,de Vries ^[10] ; Emiel J T,Rutgers ^[11] ; Yuri E M,van der Burgt ^[3] ; Elma,Meershoek-Klein Kranenbarg ^[1] ; Christa M,Cobbaert ^[3] ; Theo M,Luider ^[2] ; Wilma E,Mesker ^[1] ; Rob A E M,Tollenaar ^[1]

作者单位： Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. ^[1] Department of Neurology, Neuro-Oncology Laboratory/Clinical and Cancer Proteomics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands. ^[2] Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. ^[3] Department of Surgery, Cancer Centre, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. ^[4] Department of Surgery, Máxima Medical Center, 5504 DB Veldhoven, The Netherlands. ^[5] Department of Surgery, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands. ^[6] Department of Surgery, Albert Schweitzer Hospital, 3318 AT Dordrecht, The Netherlands. ^[7] Department of Surgery, Medisch Spectrum Twente, 7512 KZ Enschede, The Netherlands. ^[8] Department of Surgery, Spaarne Gasthuis, 2134 TM Hoofddorp, The Netherlands. ^[9] Department of Surgery, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands. ^[10] Department of Surgery, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands. ^[11]

关键词 biomarkers breast cancer clustering early detection homeostasis inter-intra patient variation liquid biopsy longitudinal analysis proteomics serum

主题词人类(Humans);女(雌)性(Female);乳腺肿瘤(Breast Neoplasms);蛋白质组(Proteome);前瞻性研究(Prospective Studies);光谱法, 质量, 基质辅助激光解吸电离(Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization);血蛋白质类(Blood Proteins)

DOI 10.3390/ijms232012399

PMID 36293255

发布时间 2022-10-30

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