Candesartan Attenuates Cisplatin-Induced Lung Injury by Modulating Oxidative Stress, Inflammation, and TLR-4/NF-κB, JAK1/STAT3, and Nrf2/HO-1 Signaling.

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作者： Ahmed M,Atwa ^[1] ; Omnia A M,Abd El-Ghafar ^[2] ; Emad H M,Hassanein ^[3] ; Somya E,Mahdi ^[4] ; Ghadir A,Sayed ^[5] ; Reem S,Alruhaimi ^[6] ; Haifa A,Alqhtani ^[6] ; Mohammed F,Alotaibi ^[7] ; Ayman M,Mahmoud ^[8]

作者单位： Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo 11829, Egypt. ^[1] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef 62521, Egypt. ^[2] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt. ^[3] Department of Physiology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt. ^[4] Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Cairo 11829, Egypt. ^[5] Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia. ^[6] Physiology Department, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. ^[7] Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt. ^[8] Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester M1 5GD, UK. ^[9]

关键词 candesartan chemotherapy inflammation lung injury oxidative stress

DOI 10.3390/ph15101222

PMID 36297334

发布时间 2022-10-30

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