首页> Nature neuroscience> Age-related Huntington's disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy.

Age-related Huntington's disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy.

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第一作者： Young Mi,Oh

第一单位： Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.

作者： Young Mi,Oh ^[1] ; Seong Won,Lee ^[1] ; Woo Kyung,Kim ^[1] ; Shawei,Chen ^[1] ; Victoria A,Church ^[1] ; Kitra,Cates ^[1] ; Tiandao,Li ^[2] ; Bo,Zhang ^[2] ; Roland E,Dolle ^[3] ; Sonika,Dahiya ^[4] ; Stephen C,Pak ^[5] ; Gary A,Silverman ^[5] ; David H,Perlmutter ^[5] ; Andrew S,Yoo ^[6]

作者单位： Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA. ^[1] Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.;Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA. ^[2] Department of Biochemistry, Washington University School of Medicine, St. Louis, MO, USA. ^[3] Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. ^[4] Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA. ^[5] Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA. yooa@wustl.edu.;Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA. yooa@wustl.edu. ^[6]

医学主题词人类(Humans);动物(Animals);杭廷顿病(Huntington Disease);纹状体(Corpus Striatum);神经元(Neurons);自噬(Autophagy);微RNAs(MicroRNAs);疾病恶化(Disease Progression);疾病模型, 动物(Disease Models, Animal)

DOI 10.1038/s41593-022-01185-4

PMID 36303071

发布时间 2024-12-05

基金项目

R35 GM142917/GM/NIGMS NIH HHS/United States R01 NS107488/NS/NINDS NIH HHS/United States P01 DK096990/DK/NIDDK NIH HHS/United States T32 GM139774/GM/NIGMS NIH HHS/United States RF1 AG056296/AG/NIA NIH HHS/United States T32 GM007067/GM/NIGMS NIH HHS/United States

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