Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease.

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第一作者： Hangchen,Hu

第一单位： School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.

作者： Hangchen,Hu ^[1] ; Qian,Wang ^[2] ; Haixia,Su ^[3] ; Qiang,Shao ^[4] ; Wenfeng,Zhao ^[2] ; Guofeng,Chen ^[2] ; Minjun,Li ^[2] ; Yechun,Xu ^[2]

作者单位： School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China. ^[1] CAS Key Laboratory of Receptor Research and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. ^[2] University of Chinese Academy of Sciences, Beijing, 100049, China. ^[3] School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. ^[4] Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201203, China. ^[5]

关键词 Allosteric Modulator Cysteine 270 Drug Design Papain-Like Protease SARS-CoV-2

主题词人类(Humans);半胱氨酸(Cysteine);病毒蛋白质类(Viral Proteins);肽水解酶类(Peptide Hydrolases);抗病毒药(Antiviral Agents);蛋白酶抑制药(Protease Inhibitors)

DOI 10.1002/anie.202212378

PMID 36308706

发布时间 2023-01-26

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