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首页> Biochemical and biophysical research communications> Targeted inhibition of TXNRD1 prevents cartilage extracellular matrix degeneration by activating Nrf2 pathway in osteoarthritis.

Targeted inhibition of TXNRD1 prevents cartilage extracellular matrix degeneration by activating Nrf2 pathway in osteoarthritis.

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作者： Jianhui,Liang ^[1] ; Song,Wang ^[1] ; Jiawei,Hu ^[1] ; Xin,Hong ^[1] ; Meisong,Zhu ^[1] ; Xuqiang,Liu ^[1] ; Momen,Alswadeh ^[1] ; Fengbo,Mo ^[2] ; Min,Dai ^[3]

作者单位： Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China. ^[1] Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China. Electronic address: doctormfb@126.com. ^[2] Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China. Electronic address: daiminyisheng@163.com. ^[3]

关键词 Auranofin Extracellular matrix Nrf2 pathway Osteoarthritis TXNRD1

主题词动物(Animals);小鼠(Mice);金诺芬(Auranofin);软骨, 关节(Cartilage, Articular);软骨细胞(Chondrocytes);细胞外基质(Extracellular Matrix);白细胞介素1β(Interleukin-1beta);NF-E2相关因子2(NF-E2-Related Factor 2);骨关节炎(Osteoarthritis);硫氧还蛋白还原酶1(Thioredoxin Reductase 1)

DOI 10.1016/j.bbrc.2022.10.059

PMID 36308906

发布时间 2022-12-12

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Biochemical and biophysical research communications

267-276页

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