Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling.

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作者： Yu,Qian ^[1] ; Zhengxiong,Ma ^[2] ; Chunhong,Liu ^[3] ; Xinzhi,Li ^[3] ; Xinyan,Zhu ^[2] ; Na,Wang ^[2] ; Zhenmei,Xu ^[2] ; Ruixue,Xia ^[2] ; Jiale,Liang ^[2] ; Yaning,Duan ^[2] ; Han,Yin ^[2] ; Yangjie,Xiong ^[2] ; Anqi,Zhang ^[3] ; Changyou,Guo ^[3] ; Zheng,Chen ^[3] ; Zhiwei,Huang ^[3] ; Yuanzheng,He ^[4]

作者单位： Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, Harbin Institute of Technology, Harbin 150001, China; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China. ^[1] Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, Harbin Institute of Technology, Harbin 150001, China. ^[2] HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China. ^[3] Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, Harbin Institute of Technology, Harbin 150001, China. Electronic address: ajian.he@hit.edu.cn. ^[4]

关键词 ADGRL3 G(12) coupling G-protein-coupling selectivity aGPCR

主题词配体(Ligands);冷冻电子显微镜检查(Cryoelectron Microscopy);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);GTP结合蛋白质类(GTP-Binding Proteins)

DOI 10.1016/j.molcel.2022.10.009

PMID 36309016

发布时间 2023-01-09

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