Oral-recombinant Methioninase Lowers the Effective Dose and Eliminates Toxicity of Cisplatinum for Primary Osteosarcoma of the Mammary Gland in a Patient-derived Orthotopic Xenograft Mouse Model.

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作者： Noriyuki,Masaki ^[1] ; Qinghong,Han ^[2] ; Nathaniel F,Wu ^[3] ; Carissa,Samonte ^[1] ; Justin,Wu ^[4] ; Chihiro,Hozumi ^[1] ; Koya,Obara ^[5] ; Yutaro,Kubota ^[6] ; Yusuke,Aoki ^[1] ; Jun,Miyazaki ^[3] ; Robert M,Hoffman ^[1]

作者单位： AntiCancer Inc, San Diego, CA, U.S.A. ^[1] Graduate School of Medicine, International University of Health and Welfare, Tokyo, Japan. ^[2] Department of Surgery, University of California, San Diego, CA, U.S.A. ^[3] Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, U.S.A. ^[4] Department of General Surgery, Kaiser Permanente San Diego Medical Center, San Diego, CA, U.S.A. ^[5] AntiCancer Japan Inc, Narita, Japan. ^[6] Department of Urology, School of Medicine, International University of Health and Welfare, Narita, Japan. ^[7] AntiCancer Inc, San Diego, CA, U.S.A.: all@anticancer.com. ^[8]

关键词 Breast osteosarcoma Hoffman effect PDOX cisplatinum combination therapy efficacy methioninase methionine addiction nude mice oral administration

主题词小鼠(Mice);人类(Humans);动物(Animals);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);小鼠, 裸(Mice, Nude);重组蛋白质类(Recombinant Proteins);顺铂(Cisplatin);骨肉瘤(Osteosarcoma);疾病模型, 动物(Disease Models, Animal);骨肿瘤(Bone Neoplasms);甲硫氨酸(Methionine)

DOI 10.21873/invivo.12994

PMID 36309364

发布时间 2022-12-21

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Oral-recombinant Methioninase Lowers the Effective Dose and Eliminates Toxicity of Cisplatinum for Primary Osteosarcoma of the Mammary Gland in a Patient-derived Orthotopic Xenograft Mouse Model.

In vivo (Athens, Greece)

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Oral-recombinant Methioninase Lowers the Effective Dose and Eliminates Toxicity of Cisplatinum for Primary Osteosarcoma of the Mammary Gland in a Patient-derived Orthotopic Xenograft Mouse Model.

In vivo (Athens, Greece)

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In vivo (Athens, Greece)

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