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The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside.

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第一作者： María B,Birkisdóttir

第一单位： Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.;Oncode Institute, Utrecht, Netherlands.

作者： María B,Birkisdóttir ^[1] ; Ivar,van Galen ^[1] ; Renata M C,Brandt ^[2] ; Sander,Barnhoorn ^[2] ; Nicole,van Vliet ^[2] ; Claire,van Dijk ^[3] ; Bhawani,Nagarajah ^[4] ; Sandra,Imholz ^[4] ; Conny T,van Oostrom ^[4] ; Erwin,Reiling ^[4] ; Ákos,Gyenis ^[5] ; Pier G,Mastroberardino ^[6] ; Dick,Jaarsma ^[7] ; Harry,van Steeg ^[4] ; Jan H J,Hoeijmakers ^[8] ; Martijn E T,Dollé ^[4] ; Wilbert P,Vermeij ^[1]

作者单位： Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.;Oncode Institute, Utrecht, Netherlands. ^[1] Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands. ^[2] Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.;Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands. ^[3] Centre for Health Protection, National Institute for Public Health and the Environment, (RIVM), Bilthoven, Netherlands. ^[4] , Faculty of Medicine, CECAD, Institute for Genome Stability in Aging and Disease, University of Cologne, Cologne, Germany. ^[5] Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.;IFOM-The FIRC Institute of Molecular Oncology, Milan, Italy.;Department of Life, Health, and Environmental Sciences, University of L'Aquila, L'Aquila, Italy. ^[6] Department of Neuroscience, Erasmus University Medical Center, Rotterdam, Netherlands. ^[7] Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.;Oncode Institute, Utrecht, Netherlands.;Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.;, Faculty of Medicine, CECAD, Institute for Genome Stability in Aging and Disease, University of Cologne, Cologne, Germany. ^[8]

关键词 DNA damage repair NAD aging anti-aging interventions dietary restriction mimetics pharmacological screening progeria

DOI 10.3389/fragi.2022.1005322

PMID 36313181

发布时间 2023-03-01

基金项目

P01 AG017242/AG/NIA NIH HHS/United States

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The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside.

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The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside.

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