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An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression.

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第一作者: Eddie,Cano-Gamez
第一单位: Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.;Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
作者: Eddie,Cano-Gamez [1] ; Katie L,Burnham [2] ; Cyndi,Goh [3] ; Alice,Allcock [4] ; Zunaira H,Malick [4] ; Lauren,Overend [4] ; Andrew,Kwok [4] ; David A,Smith [5] ; Hessel,Peters-Sengers [6] ; David,Antcliffe [7] ; GAinS Investigators [8] ; Stuart,McKechnie [9] ; Brendon P,Scicluna [10] ; Tom,van der Poll [7] ; Anthony C,Gordon [11] ; Charles J,Hinds [2] ; Emma E,Davenport [5] ; Julian C,Knight ; Nigel,Webster ; Helen,Galley ; Jane,Taylor ; Sally,Hall ; Jenni,Addison ; Sian,Roughton ; Heather,Tennant ; Achyut,Guleri ; Natalia,Waddington ; Dilshan,Arawwawala ; John,Durcan ; Alasdair,Short ; Karen,Swan ; Sarah,Williams ; Susan,Smolen ; Christine,Mitchell-Inwang ; Tony,Gordon ; Emily,Errington ; Maie,Templeton ; Pyda,Venatesh ; Geraldine,Ward ; Marie,McCauley ; Simon,Baudouin ; Charley,Higham ; Jasmeet,Soar ; Sally,Grier ; Elaine,Hall ; Stephen,Brett ; David,Kitson ; Robert,Wilson ; Laura,Mountford ; Juan,Moreno ; Peter,Hall ; Jackie,Hewlett ; Stuart,McKechnie ; Christopher,Garrard ; Julian,Millo ; Duncan,Young ; Paula,Hutton ; Penny,Parsons ; Alex,Smiths ; Roser,Faras-Arraya ; Jasmeet,Soar ; Parizade,Raymode ; Jonathan,Thompson ; Sarah,Bowrey ; Sandra,Kazembe ; Natalie,Rich ; Prem,Andreou ; Dawn,Hales ; Emma,Roberts ; Simon,Fletcher ; Melissa,Rosbergen ; Georgina,Glister ; Jeronimo Moreno,Cuesta ; Julian,Bion ; Joanne,Millar ; Elsa Jane,Perry ; Heather,Willis ; Natalie,Mitchell ; Sebastian,Ruel ; Ronald,Carrera ; Jude,Wilde ; Annette,Nilson ; Sarah,Lees ; Atul,Kapila ; Nicola,Jacques ; Jane,Atkinson ; Abby,Brown ; Heather,Prowse ; Anton,Krige ; Martin,Bland ; Lynne,Bullock ; Donna,Harrison ; Gary,Mills ; John,Humphreys ; Kelsey,Armitage ; Shond,Laha ; Jacqueline,Baldwin ; Angela,Walsh ; Nicola,Doherty ; Stephen,Drage ; Laura,Ortiz-Ruiz de Gordoa ; Sarah,Lowes ; Charley,Higham ; Helen,Walsh ; Verity,Calder ; Catherine,Swan ; Heather,Payne ; David,Higgins ; Sarah,Andrews ; Sarah,Mappleback ; Charles,Hind ; Chris,Garrard ; D,Watson ; Eleanor,McLees ; Alice,Purdy ; Martin,Stotz ; Adaeze,Ochelli-Okpue ; Stephen,Bonner ; Iain,Whitehead ; Keith,Hugil ; Victoria,Goodridge ; Louisa,Cawthor ; Martin,Kuper ; Sheik,Pahary ; Geoffrey,Bellingan ; Richard,Marshall ; Hugh,Montgomery ; Jung Hyun,Ryu ; Georgia,Bercades ; Susan,Boluda ; Andrew,Bentley ; Katie,Mccalman ; Fiona,Jefferies ; Julian,Knight ; Emma,Davenport ; Katie,Burnham ; Narelle,Maugeri ; Jayachandran,Radhakrishnan ; Yuxin,Mi ; Alice,Allcock ; Cyndi,Goh
作者单位: Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.;Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK. [1] Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK. [2] Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.;Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK. [3] Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. [4] Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.;Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford OX3 7BN, UK. [5] Centre for Experimental and Molecular Medicine, Amsterdam University Medical Centers, University of Amsterdam, 1100 DD Amsterdam Southeast, Netherlands.;Department of Epidemiology and Data Science, Amsterdam Public Health, Amsterdam University Medical Centers, University of Amsterdam, 1100 DD Amsterdam Southeast, Netherlands.;Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, 1100 DD Amsterdam Southeast, Netherlands. [6] Division of Anaesthesia, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK. [7] Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK. [8] Centre for Experimental and Molecular Medicine, Amsterdam University Medical Centers, University of Amsterdam, 1100 DD Amsterdam Southeast, Netherlands.;Department of Applied Biomedical Science, Faculty of Health Sciences, Materi Dei Hospital, University of Malta, Msida MSD 2080, Malta.;Centre for Molecular Medicine and Biobanking, University of Malta, Msida MSD 2080, Malta. [9] Centre for Experimental and Molecular Medicine, Amsterdam University Medical Centers, University of Amsterdam, 1100 DD Amsterdam Southeast, Netherlands. [10] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London EC1M 6BQ, UK. [11]
DOI 10.1126/scitranslmed.abq4433
PMID 36322631
发布时间 2024-06-07
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