Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project.

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作者： Gordon W,Blair ^[1] ; Michael S,Stringer ^[1] ; Michael J,Thrippleton ^[1] ; Francesca M,Chappell ^[1] ; Kirsten,Shuler ^[1] ; Iona,Hamilton ^[1] ; Daniela Jaime,Garcia ^[1] ; Fergus N,Doubal ^[1] ; Anna,Kopczak ^[2] ; Marco,Duering ^[2] ; Michael,Ingrisch ^[2] ; Danielle,Kerkhofs ^[3] ; Julie,Staals ^[3] ; Hilde,van den Brink ^[4] ; Tine,Arts ^[5] ; Walter H,Backes ^[6] ; Robert,van Oostenbrugge ^[3] ; Geert Jan,Biessels ^[4] ; Martin,Dichgans ^[2] ; Joanna M,Wardlaw ^[7]

作者单位： Brain Research Imaging Centre, Centre for Clinical Brain Sciences, UK Dementia Institute Centre at the University of Edinburgh, Edinburgh, UK. ^[1] Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany. ^[2] Department of neurology, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, the Netherlands. ^[3] Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands. ^[4] Department of Radiology, Centre for Image Sciences, University Medical Center Utrecht, Utrecht, the Netherlands. ^[5] Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Schools for Mental Health & Neuroscience and Cardiovascular Disease, Maastricht, the Netherlands. ^[6] German Center for Neurodegenerative Diseases, DZNE, Munich, Germany. ^[7] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. ^[8]

关键词 BBB, blood brain barrier BOLD, blood oxygen level dependent BP, blood pressure BPv, blood pressure variability Blood-brain barrier permeability CADASIL CADASIL, cerebral autosomal dominant arteriopathy with leukoencephalopathy and subcortical infarcts CBF, cerebral blood flow CERAD+, consortium to establish a disease registry for Alzheimer's disease plus battery CO2, carbon dioxide CSF, cerebrospinal fluid CVR, cerebrovascular reactivity Cerebral small vessel disease Cerebrovascular reactivity DCE, dynamic contrast enhanced EtCO2, end-tidal carbon dioxide GM, grey matter MMSE, mini-mental state examination MRI MoCA, Montreal cognitive exam NIHSS, national institute for health stroke scale PI, pulsatility index PVS, perivascular space RSSI, recent small subcortical infarct SVDs, small vessel diseases WM, white matter WMH, white matter hyperintensity

DOI 10.1016/j.cccb.2021.100020

PMID 36324725

发布时间 2022-12-29

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Cerebral circulation - cognition and behavior

2021年2卷

100020页

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Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project.

Cerebral circulation - cognition and behavior

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Cerebral circulation - cognition and behavior

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Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project.

Cerebral circulation - cognition and behavior

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Cerebral circulation - cognition and behavior

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