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Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis.

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作者单位: St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY. [1] The David Rockefeller Graduate Program, Rockefeller University, New York, NY. [2] Laboratory of Lymphocyte Activation and Susceptibility to EBV Infection, INSERM UMR1163, Paris, France. [3] Imagine Institute, University of Paris Cité, Paris, France. [4] Cell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. [5] Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France. [6] Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. [7] School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. [8] Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. [9] Department of Virology, Cochin Hospital, University of Paris, Paris, France. [10] Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Philadelphia, PA. [11] Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA. [12] Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. [13] Pediatric Immunology and Hematology Department, Necker Hospital for Sick Children Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France. [14] Clinical Immunology Department, Saint Louis Hospital, AP-HP Université de Paris, Paris, France. [15] INSERM UMR1126, Institut de Recherche Saint-Louis, Université de Paris, Paris, France. [16] Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. [17] Department of Microbiology and Immunology, Laboratory of Clinical Bacteriology and Mycology, KU Leuven, Leuven, Belgium. [18] Department of Pediatric Pulmonology, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey. [19] Division of Pediatric Infectious Diseases, Department of Pediatrics, Selcuk University Faculty of Medicine, Konya, Turkey. [20] Department of Pediatric Hematology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey. [21] Division of Pediatric Immunology and Rheumatology, Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany. [22] Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France. [23] Division of Pediatric Allergy and Immunology, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey. [24] Division of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran. [25] Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran. [26] College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. [27] Department of Pediatrics, Necker Hospital for Sick Children, Paris, France. [28] Howard Hughes Medical Institute, New York, NY. [29]
DOI 10.1084/jem.20220484
PMID 36326697
发布时间 2023-03-09
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