换一批Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative.
第一作者：
Guillaume,Butler-Laporte
第一单位：
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.;Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
作者：
Guillaume,Butler-Laporte [1]
;
Gundula,Povysil [2]
;
Jack A,Kosmicki [3]
;
Elizabeth T,Cirulli [4]
;
Theodore,Drivas [5]
;
Simone,Furini [6]
;
Chadi,Saad [7]
;
Axel,Schmidt [8]
;
Pawel,Olszewski [9]
;
Urszula,Korotko [10]
;
Mathieu,Quinodoz [11]
;
Elifnaz,Çelik [12]
;
Kousik,Kundu [13]
;
Klaudia,Walter [14]
;
Junghyun,Jung [15]
;
Amy D,Stockwell [16]
;
Laura G,Sloofman [17]
;
Daniel M,Jordan [18]
;
Ryan C,Thompson [19]
;
Diane,Del Valle [20]
;
Nicole,Simons [20]
;
Esther,Cheng [20]
;
Robert,Sebra [21]
;
Eric E,Schadt [21]
;
Seunghee,Kim-Schulze [22]
;
Sacha,Gnjatic [20]
;
Miriam,Merad [23]
;
Joseph D,Buxbaum [17]
;
Noam D,Beckmann [23]
;
Alexander W,Charney [24]
;
Bartlomiej,Przychodzen [25]
;
Timothy,Chang [26]
;
Tess D,Pottinger [2]
;
Ning,Shang [27]
;
Fabian,Brand [28]
;
Francesca,Fava [29]
;
Francesca,Mari [29]
;
Karolina,Chwialkowska [10]
;
Magdalena,Niemira [30]
;
Szymon,Pula [9]
;
J Kenneth,Baillie [31]
;
Alex,Stuckey [32]
;
Antonio,Salas [33]
;
Xabier,Bello [33]
;
Jacobo,Pardo-Seco [33]
;
Alberto,Gómez-Carballa [33]
;
Irene,Rivero-Calle [34]
;
Federico,Martinón-Torres [34]
;
Andrea,Ganna [35]
;
Konrad J,Karczewski [36]
;
Kumar,Veerapen [36]
;
Mathieu,Bourgey [37]
;
Guillaume,Bourque [38]
;
Robert Jm,Eveleigh [37]
;
Vincenzo,Forgetta [39]
;
David,Morrison [39]
;
David,Langlais [40]
;
Mark,Lathrop [40]
;
Vincent,Mooser [41]
;
Tomoko,Nakanishi [42]
;
Robert,Frithiof [43]
;
Michael,Hultström [44]
;
Miklos,Lipcsey [45]
;
Yanara,Marincevic-Zuniga [46]
;
Jessica,Nordlund [46]
;
Kelly M,Schiabor Barrett [4]
;
William,Lee [4]
;
Alexandre,Bolze [4]
;
Simon,White [4]
;
Stephen,Riffle [4]
;
Francisco,Tanudjaja [4]
;
Efren,Sandoval [4]
;
Iva,Neveux [47]
;
Shaun,Dabe [48]
;
Nicolas,Casadei [49]
;
Susanne,Motameny [50]
;
Manal,Alaamery [51]
;
Salam,Massadeh [51]
;
Nora,Aljawini [51]
;
Mansour S,Almutairi [51]
;
Yaseen M,Arabi [52]
;
Saleh A,Alqahtani [53]
;
Fawz S,Al Harthi [54]
;
Amal,Almutairi [54]
;
Fatima,Alqubaishi [54]
;
Sarah,Alotaibi [54]
;
Albandari,Binowayn [54]
;
Ebtehal A,Alsolm [54]
;
Hadeel,El Bardisy [54]
;
Mohammad,Fawzy [54]
;
Fang,Cai [16]
;
Nicole,Soranzo [14]
;
Adam,Butterworth [14]
;
COVID-19 Host Genetics Initiative [26]
;
DeCOI Host Genetics Group [26]
;
GEN-COVID Multicenter Study (Italy) [55]
;
Mount Sinai Clinical Intelligence Center [56]
;
GEN-COVID consortium (Spain) [57]
;
GenOMICC Consortium [57]
;
Japan COVID-19 Task Force [57]
;
Regeneron Genetics Center [57]
;
Daniel H,Geschwind [58]
;
Stephanie,Arteaga [58]
;
Alexis,Stephens [58]
;
Manish J,Butte [58]
;
Paul C,Boutros [57]
;
Takafumi N,Yamaguchi [58]
;
Shu,Tao [59]
;
Stefan,Eng [60]
;
Timothy,Sanders [16]
;
Paul J,Tung [25]
;
Michael E,Broudy [11]
;
Yu,Pan [61]
;
Alfredo,Gonzalez [61]
;
Nikhil,Chavan [62]
;
Ruth,Johnson [63]
;
Bogdan,Pasaniuc [62]
;
Brian,Yaspan [64]
;
Sandra,Smieszek [65]
;
Carlo,Rivolta [66]
;
Stephanie,Bibert [67]
;
Pierre-Yves,Bochud [68]
;
Maciej,Dabrowski [69]
;
Pawel,Zawadzki [70]
;
Mateusz,Sypniewski [71]
;
Elżbieta,Kaja [72]
;
Pajaree,Chariyavilaskul [72]
;
Voraphoj,Nilaratanakul [73]
;
Nattiya,Hirankarn [74]
;
Vorasuk,Shotelersuk [75]
;
Monnat,Pongpanich [76]
;
Chureerat,Phokaew [77]
;
Wanna,Chetruengchai [78]
;
Katsushi,Tokunaga [79]
;
Masaya,Sugiyama [80]
;
Yosuke,Kawai [81]
;
Takanori,Hasegawa [82]
;
Tatsuhiko,Naito [83]
;
Ho,Namkoong [74]
;
Ryuya,Edahiro [84]
;
Akinori,Kimura [54]
;
Seishi,Ogawa [85]
;
Takanori,Kanai [47]
;
Koichi,Fukunaga [4]
;
Yukinori,Okada [49]
;
Seiya,Imoto [86]
;
Satoru,Miyano [87]
;
Serghei,Mangul [49]
;
Malak S,Abedalthagafi [88]
;
Hugo,Zeberg [10]
;
Joseph J,Grzymski [7]
;
Nicole L,Washington [7]
;
Stephan,Ossowski [89]
;
Kerstin U,Ludwig [90]
;
Eva C,Schulte [91]
;
Olaf,Riess [29]
;
Marcin,Moniuszko [3]
;
Miroslaw,Kwasniewski [92]
;
Hamdi,Mbarek ;
Said I,Ismail ;
Anurag,Verma ;
David B,Goldstein ;
Krzysztof,Kiryluk ;
Alessandra,Renieri ;
Manuel A R,Ferreira ;
J Brent,Richards
作者单位：
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.;Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
[1]
Institute for Genomic Medicine, Columbia University, New York city, New York, United States of America.
[2]
Regeneron Genetics Center, Tarrytown, New York, United States of America.
[3]
Helix, San Mateo, California, United States of America.
[4]
Division of Human Genetics, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.;Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.;Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
[5]
Department of Medical Biotechnologies, Med Biotech Hub and Competence Center, University of Siena, Siena, Italy.
[6]
Qatar Genome Program, Qatar Foundation Research, Development and Innovation, Qatar Foundation, Doha, Qatar.
[7]
Institute of Human Genetics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany.
[8]
IMAGENE.ME SA, Bialystok, Poland.
[9]
IMAGENE.ME SA, Bialystok, Poland.;Centre for Bioinformatics and Data Analysis, Medical University of Bialystok, Bialystok, Poland.
[10]
Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.;Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.;Department of Ophthalmology, University Hospital Basel, Basel, Switzerland.
[11]
Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.;Department of Ophthalmology, University Hospital Basel, Basel, Switzerland.
[12]
Department of Haematology, University of Cambridge, Cambridge, United Kingdom.;Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom.
[13]
Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom.
[14]
Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America.;Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
[15]
Genentech Inc, South San Francisco, California, United States of America.
[16]
Seaver Autism Center for Research and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America.
[17]
Mount Sinai Clnical Intelligence Center, Charles Bronfman Institute for Personalized Medicine, Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America.
[18]
Icahn Institute of Data Science and Genomics Technology, New York city, New York, United States of America.
[19]
Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America.
[20]
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York city,New York, United States of America.
[21]
Department of Oncological Science, Human Immune Monitoring Center, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America.
[22]
Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America.
[23]
Mount Sinai Clinical Intelligence Center; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America.
[24]
Vanda Pharmaceuticals, Washington, District of Columbia, United States of America.
[25]
Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America.
[26]
Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York city, New York, United States of America.
[27]
Institute of Genomic Statistics and Bioinformatics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany.
[28]
Department of Medical Biotechnologies, Med Biotech Hub and Competence Center, University of Siena, Siena, Italy.;Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.;Medical Genetics, University of Siena, Siena, Italy.
[29]
Centre for Clinical Research, Medical University of Bialystok, Bialystok, Poland.
[30]
Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.;MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.;Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.;Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
[31]
Genomics England, London, United Kingdom.
[32]
Unidade de Xenética, Instituto de Ciencias Forenses (INCIFOR), Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigaciones Sanitarias, Hospital Clínico Universitario de Santiago (SERGAS), Santiago de Compostela, Galicia, Spain.;Genetics, Vaccines and Infections Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, Spain.;Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBER-ES), Madrid, Spain.
[33]
Genetics, Vaccines and Infections Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, Spain.;Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBER-ES), Madrid, Spain.;Translational Pediatrics and Infectious Diseases, Department of Pediatrics, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
[34]
Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.;Massachusetts General Hospital, Harvard Medical School, Boston, Massachussets, United States of America.
[35]
Stanley Center for Psychiatric Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.;Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
[36]
Canadian Centre for Computational Genomics, McGill University, Montréal, Québec, Canada.;McGill Genome Center, McGill University, Montréal, Québec, Canada.
[37]
Canadian Centre for Computational Genomics, McGill University, Montréal, Québec, Canada.;McGill Genome Center, McGill University, Montréal, Québec, Canada.;Department of Human Genetics, McGill University, Montréal, Québec, Canada.
[38]
Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
[39]
McGill Genome Center, McGill University, Montréal, Québec, Canada.;Department of Human Genetics, McGill University, Montréal, Québec, Canada.
[40]
Department of Human Genetics, McGill University, Montréal, Québec, Canada.
[41]
Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.;Department of Human Genetics, McGill University, Montréal, Québec, Canada.;Kyoto-McGill International Collaborative School in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.;Research Fellow, Japan Society for the Promotion of Science, Tokyo, Japan.
[42]
Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
[43]
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.;Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.;Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.;Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
[44]
Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.;Hedenstierna Laboratory, CIRRUS, Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
[45]
Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
[46]
Center for Genomic Medicine, Desert Research Institute, Reno, Nevada United States of America.
[47]
Renown Health, Reno, Nevada, United States of America.
[48]
Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany.;NGS Competence Center Tuebingen, Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany.
[49]
West German Genome Center, site Cologne, University of Cologne, Cologne, Germany.;Cologne Center for Genomics, University of Cologne, Cologne, Germany.
[50]
Developmental Medicine Department, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.;Saudi Human Genome Project at King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
[51]
Ministry of the National Guard Health Affairs, King Abdullah International Medical Research Center and King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
[52]
Liver Transplant Unit, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.;Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland, United States of America.
[53]
Genomics Research Department, Saudi Human Genome Project, King Fahad Medical City and King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
[54]
Department of Pediatrics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America.
[55]
Department of Pediatrics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America.;Department of Microbiology, Immunology, and Molecular Genetics (MIMG), David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America.
[56]
Department of Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America.
[57]
Office of Health Informatics and Analytics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America.
[58]
Department of Computer Science, McGill University, Montréal, Québec, Canada.
[59]
Department of Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America.;Department of Computational Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America.;Department of Pathology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America.
[60]
Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland.
[61]
MNM Bioscience Inc., Cambridge, Massachusetts, United States of America.
[62]
MNM Bioscience Inc., Cambridge, Massachusetts, United States of America.;Faculty of Physics, Adam Mickiewicz University, Poznan, Poland.
[63]
MNM Bioscience Inc., Cambridge, Massachusetts, United States of America.;Department of Medical Chemistry and Laboratory Medicine, Poznań University of Medical Sciences, Poznań, Poland.
[64]
Clinical Pharmacokinetics and Pharmacogenomics Research Unit, Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
[65]
Healthcare-associated Infection Research Group STAR (Special Task Force for Activating Research) and Division of Infectious Diseases, Department of Medicine,Chulalongkorn University, Bangkok, Thailand.
[66]
Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
[67]
Center of Excellence for Medical Genomics, Medical Genomics Cluster, and Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
[68]
Department of Mathematics and Computer Science, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
[69]
Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
[70]
Center of Excellence for Medical Genomics, Medical Genomics Cluster, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
[71]
Genome Medical Science Project, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.
[72]
Genome Medical Science Project, National Center for Global Health and Medicine (NCGM), Tokyo, Japan.
[73]
M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
[74]
Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.;Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
[75]
Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
[76]
Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.;Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
[77]
Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan.
[78]
Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.;Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.;Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden.
[79]
Division of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
[80]
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
[81]
Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.;Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.;Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.;Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.;Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan.
[82]
Division of Health Medical Intelligence, Human Genome Center, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
[83]
Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America.
[84]
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
[85]
Institute of Human Genetics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany.;West German Genome Center, site Bonn, University of Bonn, Bonn, Germany.
[86]
Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.;Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.;Institute of Virology, Technical University Munich/Helmholtz Zentrum München, Munich, Germany.
[87]
Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok, Poland.;Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.
[88]
Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.;Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.;Corporal Michael Crescenz VA Medical Center, Philadelphia, Pennsylvania, United States of America.
[89]
Institute for Genomic Medicine, Columbia University, New York city, New York, United States of America.;Department of Genetics & Development, Columbia University, New York city, New York, United States of America.
[90]
Institute for Genomic Medicine, Columbia University, New York city, New York, United States of America.;Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York city, New York, United States of America.
[91]
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.;Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.;Department of Human Genetics, McGill University, Montréal, Québec, Canada.;Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.;Department of Twin Research, King's College London, London, United Kingdom.;5 Prime Sciences Inc, Montreal, Quebec, Canada.
[92]
医学主题词
人类(Humans);全基因组关联研究(Genome-Wide Association Study);疾病遗传易感性(Genetic Predisposition to Disease);Toll样受体7(Toll-Like Receptor 7)
DOI
10.1371/journal.pgen.1010367
PMID
36327219
发布时间
2025-03-16
- 浏览3
PLoS genetics
PLoS genetics
e1010367页
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