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Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition.

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第一作者： McKenzie,Crist

第一单位： Department of Internal Medicine; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, Ohio, USA.

作者： McKenzie,Crist ^[1] ; Benyamin,Yaniv ^[2] ; Sarah,Palackdharry ^[3] ; Maria A,Lehn ^[4] ; Mario,Medvedovic ^[5] ; Timothy,Stone ^[5] ; Shuchi,Gulati ^[1] ; Vidhya,Karivedu ^[6] ; Michael,Borchers ^[7] ; Bethany,Fuhrman ^[3] ; Audrey,Crago ^[3] ; Joseph,Curry ^[8] ; Ubaldo,Martinez-Outschoorn ^[9] ; Vinita,Takiar ^[10] ; Trisha M,Wise-Draper ^[11]

作者单位： Department of Internal Medicine; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, Ohio, USA. ^[1] Department of Medicine, UMass Memorial Medical Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA. ^[2] University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio, USA. ^[3] Department of Internal Medicine; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, Ohio, USA.;Division of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio, USA. ^[4] Department of Environmental Health; Division of Biostatistics and Bioinformatics, University of Cincinnati, Cincinnati, Ohio, USA. ^[5] Department of Medical Oncology Head and Neck Oncology, The Ohio State University, Columbus, Ohio, USA. ^[6] Division of Biostatistics and Bioinformatics, University of Cincinnati, Cincinnati, Ohio, USA.;Cincinnati VA Medical Center, Cincinnati, Ohio, USA. ^[7] Department of Otolaryngology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. ^[8] Department of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. ^[9] Division of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio, USA.;Cincinnati VA Medical Center, Cincinnati, Ohio, USA. ^[10] Department of Internal Medicine; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, Ohio, USA wiseth@ucmail.uc.edu. ^[11]

关键词 cytotoxicity, immunologic head and neck neoplasms immunity, cellular immunotherapy killer cells, natural

医学主题词人类(Humans);头颈部肿瘤(Head and Neck Neoplasms);癌, 鳞状细胞(Carcinoma, Squamous Cell);二甲双胍(Metformin);杀伤细胞, 天然(Killer Cells, Natural);细胞因子类(Cytokines);趋化因子CXCL1(Chemokine CXCL1)

DOI 10.1136/jitc-2022-005632

PMID 36328378

发布时间 2023-06-15

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