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Development and Validation of a Breast Cancer Polygenic Risk Score on the Basis of Genetic Ancestry Composition.

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第一作者： Elisha,Hughes

第一单位： Myriad Genetics, Inc, Salt Lake City, UT.

作者： Elisha,Hughes ^[1] ; Susanne,Wagner ^[1] ; Dmitry,Pruss ^[1] ; Ryan,Bernhisel ^[1] ; Braden,Probst ^[1] ; Victor,Abkevich ^[1] ; Timothy,Simmons ^[1] ; Brooke,Hullinger ^[1] ; Thaddeus,Judkins ^[1] ; Eric,Rosenthal ^[1] ; Benjamin,Roa ^[1] ; Susan M,Domchek ^[2] ; Charis,Eng ^[3] ; Judy,Garber ^[4] ; Monique,Gary ^[5] ; Jennifer,Klemp ^[6] ; Semanti,Mukherjee ^[7] ; Kenneth,Offit ^[7] ; Olufunmilayo I,Olopade ^[8] ; Joseph,Vijai ^[7] ; Jeffrey N,Weitzel ^[9] ; Pat,Whitworth ^[10] ; Lamis,Yehia ^[3] ; Ora,Gordon ^[11] ; Holly,Pederson ^[12] ; Allison,Kurian ^[13] ; Thomas P,Slavin ^[1] ; Alexander,Gutin ^[1] ; Jerry S,Lanchbury ^[1]

作者单位： Myriad Genetics, Inc, Salt Lake City, UT. ^[1] Basser Center for BRCA, University of Pennsylvania, Philadelphia, PA. ^[2] Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH. ^[3] Dana-Farber Cancer Institute, Boston, MA. ^[4] Grand View Health, Sellersville, PA. ^[5] The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, KS. ^[6] Memorial Sloan Kettering Cancer Center, New York, NY. ^[7] Department of Medicine, University of Chicago, Chicago, IL. ^[8] Latin American School of Oncology, Sierra Madre, CA. ^[9] Nashville Breast Center, Nashville, TN. ^[10] Providence Health and Services, Renton, WA. ^[11] Medical Breast Services, Cleveland Clinic, Cleveland, OH. ^[12] Stanford University School of Medicine, Stanford, CA. ^[13]

医学主题词人类(Humans);女(雌)性(Female);乳腺肿瘤(Breast Neoplasms);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);危险因素(Risk Factors);多因子遗传(Multifactorial Inheritance)

DOI 10.1200/PO.22.00084

PMID 36331239

发布时间 2023-07-13

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Development and Validation of a Breast Cancer Polygenic Risk Score on the Basis of Genetic Ancestry Composition.

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Development and Validation of a Breast Cancer Polygenic Risk Score on the Basis of Genetic Ancestry Composition.

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