A 1,2,3-Triazole Derivative of Quinazoline Exhibits Antitumor Activity by Tethering RNF168 to SQSTM1/P62.
第一作者:
Fu-Cheng,Wang
第一单位:
Guangdong Key Laboratory for Genome Stability & Disease Prevention, International Cancer Center, and Marshall Laboratory of Biomedical Engineering, Shenzhen University School of Medicine, Shenzhen, Guangdong 518060, PR China.;Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, Guangdong 518060, PR China.
作者:
主题词
动物(Animals);人类(Humans);小鼠(Mice);DNA修复(DNA Repair);HCT116细胞(HCT116 Cells);喹唑啉类(Quinazolines);三唑类(Triazoles);泛素蛋白连接酶类(Ubiquitin-Protein Ligases);泛素化(Ubiquitination);抗肿瘤药(Antineoplastic Agents)
DOI
10.1021/acs.jmedchem.2c00432
PMID
36331508
发布时间
2022-12-20
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Journal of medicinal chemistry
15028-15047页
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