Novel AP2238-clorgiline hybrids as multi-target agents for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.

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第一作者： Guohui,Zhong

第一单位： Department of Pharmacy, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi, PR China; Pharmaceutical College, Guangxi Medical University, Nanning 530021, Guangxi, PR China.

作者： Guohui,Zhong ^[1] ; Jie,Guo ^[2] ; Chengyun,Pang ^[3] ; Di,Su ^[3] ; Chunli,Tang ^[3] ; Lin,Jing ^[3] ; Fengling,Zhang ^[4] ; Ping,He ^[4] ; Yaqian,Yan ^[4] ; Zongji,Chen ^[4] ; Jing,Liu ^[5] ; Neng,Jiang ^[6]

作者单位： Department of Pharmacy, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi, PR China; Pharmaceutical College, Guangxi Medical University, Nanning 530021, Guangxi, PR China. ^[1] National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang 330006, PR China. ^[2] Department of Pharmacy, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi, PR China. ^[3] Pharmaceutical College, Guangxi Medical University, Nanning 530021, Guangxi, PR China. ^[4] School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, PR China. Electronic address: liujing860828@163.com. ^[5] Department of Pharmacy, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi, PR China. Electronic address: cpujnh@163.com. ^[6]

关键词 Alzheimer’s disease Cholinesterase inhibitors Clorgiline Monoamine oxidase inhibitors Multi-target agents