The Impact of the Water Evaporation Rate and Saccharide Excipients on the Oxidative Degradation of Polysorbates During Oven Drying and Spray Drying.

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作者： Joana T,Pinto ^[1] ; Manuel,Rajkovaca ^[1] ; Amrit,Paudel ^[2]

作者单位： Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010, Graz, Austria. ^[1] Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010, Graz, Austria; Institute for Process and Particle Engineering, Graz University of Technology, 8010, Graz, Austria. Electronic address: amrit.paudel@tugraz.at. ^[2]

关键词 Biopharmaceuticals Degradation Evaporation rate Polysorbate Spray-drying Sugar

主题词辅药(Excipients);聚山梨醇酯类(Polysorbates);水(Water);海藻糖(Trehalose);氧化性应激(Oxidative Stress)

DOI 10.1016/j.xphs.2022.10.029

PMID 36334810

发布时间 2023-02-14

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