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Pathogenesis of Alcohol-Associated Liver Disease.

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作者单位: Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, 68105, USA.;Department of Internal Medicine, Omaha, NE, 68198, USA. [1] Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, 68105, USA.;Department of Internal Medicine, Omaha, NE, 68198, USA.;Department of Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA. [2]
关键词 AA, Arachidonic acidADH, Alcohol dehydrogenaseAH, Alcoholic hepatitisALD, Alcohol-associated liver diseaseALDH, Aldehyde dehydrogenaseALT, Alanine transaminaseASH, Alcohol-associated steatohepatitisAST, Aspartate transaminaseAUD, Alcohol use disorderBHMT, Betaine-homocysteine-methyltransferaseCD, Cluster of differentiationCOX, CycloxygenaseCTLs, Cytotoxic T-lymphocytesCYP, Cytochrome P450CYP2E1, Cytochrome P450 2E1Cu/Zn SOD, Copper/zinc superoxide dismutaseDAMPs, Damage-associated molecular patternsDC, Dendritic cellsEDN1, Endothelin 1ER, Endoplasmic reticulumETOH, EthanolEVs, Extracellular vesiclesFABP4, Fatty acid-binding protein 4FAF2, Fas-associated factor family member 2FMT, Fecal microbiota transplantFn14, Fibroblast growth factor-inducible 14GHS-R1a, Growth hormone secretagogue receptor type 1aGI, GOsteopontinastrointestinal tractGSH Px, Glutathione peroxidaseGSSG Rdx, Glutathione reductaseGST, Glutathione-S-transferaseGWAS, Genome-wide association studiesH2O2, Hydrogen peroxideHA, HyaluronanHCC, Hepatocellular carcinomaHNE, 4-hydroxynonenalHPMA, 3-hydroxypropylmercapturic acidHSC, Hepatic stellate cellsHSD17B13, 17 beta hydroxy steroid dehydrogenase 13HSP 90, Heat shock protein 90IFN, InterferonIL, InterleukinIRF3, Interferon regulatory factor 3JAK, Janus kinaseKC, Kupffer cellsLCN2, Lipocalin 2M-D, Mallory–DenkMAA, Malondialdehyde-acetaldehyde protein adductsMAT, Methionine adenosyltransferaseMCP, Macrophage chemotactic proteinMDA, MalondialdehydeMIF, Macrophage migration inhibitory factorMn SOD, Manganese superoxide dismutaseMt, MitochondrialNK, Natural killerNKT, Natural killer T-lymphocytesOPN, OsteopontinPAMP, Pathogen-associated molecular patternsPNPLA3, Patatin-like phospholipase domain containing 3PUFA, Polyunsaturated fatty acidRIG1, Retinoic acid inducible gene 1SAH, S-adenosylhomocysteineSAM, S-adenosylmethionineSCD, Stearoyl-CoA desaturaseSTAT, Signal transduction and activator of transcriptionTIMP1, Tissue inhibitor matrix metalloproteinase 1TLR, Toll-like receptorTNF, Tumor necrosis factor-αalcoholalcohol-associated liver diseaseethanol metabolismlivermiRNA, MicroRNAp90RSK, 90?kDa ribosomal S6 kinase
DOI 10.1016/j.jceh.2022.05.004
PMID 36340300
发布时间 2024-09-06
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