Synthesis and in vitro biological evaluation of 3-ethyl-1,5-naphthyridin-2(1H)-one derivatives as potent PARP-1 selective inhibitors and PARP-1 DNA trappers.

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第一作者： Junkang,Ren

第一单位： School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, China; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China.

作者： Junkang,Ren ^[1] ; Xu,Quan ^[2] ; Ying,Liu ^[1] ; Jiani,Li ^[2] ; Xiaoyu,Zhang ^[2] ; Zhiyu,Li ^[3] ; Xiaomeng,Zhang ^[4]

作者单位： School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, China; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China. ^[1] R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China. ^[2] School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, China. Electronic address: zhiyuli@cpu.edu.cn. ^[3] R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China. Electronic address: zhangxm@sanhome.com. ^[4]

关键词 Antitumor PARP DNA Trapping PARP-1 Selectivity

主题词 DNA(DNA)

DOI 10.1016/j.bmcl.2022.129046

PMID 36343904

发布时间 2023-02-21

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Bioorganic & medicinal chemistry letters

2022年78卷

129046页

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Synthesis and in vitro biological evaluation of 3-ethyl-1,5-naphthyridin-2(1H)-one derivatives as potent PARP-1 selective inhibitors and PARP-1 DNA trappers.

Bioorganic & medicinal chemistry letters

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Bioorganic & medicinal chemistry letters

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Synthesis and in vitro biological evaluation of 3-ethyl-1,5-naphthyridin-2(1H)-one derivatives as potent PARP-1 selective inhibitors and PARP-1 DNA trappers.

Bioorganic & medicinal chemistry letters

相似文献

Bioorganic & medicinal chemistry letters

相关期刊

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