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A Pt(IV)-conjugated brain penetrant macrocyclic peptide shows pre-clinical efficacy in glioblastoma.

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作者: J L,Jimenez-Macias [1] ; Y-C,Lee [2] ; E,Miller [2] ; T,Finkelberg [3] ; M,Zdioruk [3] ; G,Berger [4] ; C E,Farquhar [2] ; M O,Nowicki [3] ; C-F,Cho [5] ; B I,Fedeles [6] ; A,Loas [2] ; B L,Pentelute [7] ; S E,Lawler [8]
作者单位: Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology and Laboratory Medicine, Legorreta Cancer Center, Brown University, Providence, RI 02903, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. [1] Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. [2] Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. [3] Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Microbiology, Bioorganic and Macromolecular Chemistry, Faculty of Pharmacy, Université Libre de Bruxelles, Brussels 1050, Belgium. [4] Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA. [5] Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. [6] Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Electronic address: blp@mit.edu. [7] Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology and Laboratory Medicine, Legorreta Cancer Center, Brown University, Providence, RI 02903, USA. Electronic address: sean_lawler@brown.edu. [8]
DOI 10.1016/j.jconrel.2022.10.051
PMID 36349615
发布时间 2023-05-02
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