Innate immune mechanisms of mRNA vaccines.

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作者： Rein,Verbeke ^[1] ; Michael J,Hogan ^[2] ; Karin,Loré ^[3] ; Norbert,Pardi ^[4]

作者单位： Ghent Research Group on Nanomedicines, Faculty of Pharmacy, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium; Department of Biochemistry and Molecular Biology, University of British Columbia, BC V6T 1Z4, Vancouver, Canada. Electronic address: rein.verbeke@ugent.be. ^[1] Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. ^[2] Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 171 64 Solna, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. ^[3] Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: pnorbert@pennmedicine.upenn.edu. ^[4]

关键词 SARSCoV- 2 vaccine T cell adjuvant dendritic cell germinal center innate immunity ionizable lipid lipid nanoparticle mRNA vaccine neutralizing antibody nucleoside modification

主题词人类(Humans);疫苗, 合成(Vaccines, Synthetic);RNA, 信使(RNA, Messenger);免疫, 先天(Immunity, Innate)

DOI 10.1016/j.immuni.2022.10.014

PMID 36351374

发布时间 2024-09-23

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