Blood metabolomes as non-invasive biomarkers and targets of metabolic interventions for doxorubicin and trastuzumab-induced cardiotoxicity.

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作者： Chanisa,Thonusin ^[1] ; Wichwara,Nawara ^[2] ; Thawatchai,Khuanjing ^[3] ; Nanthip,Prathumsup ^[2] ; Apiwan,Arinno ^[3] ; Benjamin,Ongnok ^[1] ; Busarin,Arunsak ^[2] ; Sirawit,Sriwichaiin ^[3] ; Siriporn C,Chattipakorn ^[1] ; Nipon,Chattipakorn ^[2]

作者单位： Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. ^[1] Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. ^[2] Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand. ^[3] Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand. ^[4] Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. nchattip@gmail.com. ^[5] Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. nchattip@gmail.com. ^[6] Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand. nchattip@gmail.com. ^[7]

关键词 Cardiotoxicity Doxorubicin Heart failure Metabolome Metabolomics Trastuzumab

主题词男(雄)性(Male);大鼠(Rats);动物(Animals);大鼠, Wistar(Rats, Wistar);多柔比星(Doxorubicin);代谢组(Metabolome)

DOI 10.1007/s00204-022-03412-0

PMID 36357623

发布时间 2023-02-01

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