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CTCF blocks antisense transcription initiation at divergent promoters.

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第一作者： Jing,Luan

第一单位： Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

作者： Jing,Luan ^[1] ; Marit W,Vermunt ^[2] ; Camille M,Syrett ^[3] ; Allison,Coté ^[4] ; Jacob M,Tome ^[5] ; Haoyue,Zhang ^[6] ; Anran,Huang ^[2] ; Jennifer M,Luppino ^[7] ; Cheryl A,Keller ^[8] ; Belinda M,Giardine ^[8] ; Shiping,Zhang ^[9] ; Margaret C,Dunagin ^[10] ; Zhe,Zhang ^[9] ; Eric F,Joyce ^[7] ; John T,Lis ^[11] ; Arjun,Raj ^[4] ; Ross C,Hardison ^[8] ; Gerd A,Blobel ^[12]

作者单位： Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[1] Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. ^[2] Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.;Clarion Healthcare, LLC, Boston, MA, USA. ^[3] Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.;Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA. ^[4] Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.;Shape Therapeutics Inc, Seattle, WA, USA. ^[5] Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.;Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China. ^[6] Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA. ^[7] Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA. ^[8] Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. ^[9] Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. ^[10] Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA. ^[11] Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. blobel@chop.edu. ^[12]

医学主题词转录, 遗传(Transcription, Genetic);启动区, 遗传(Promoter Regions, Genetic);染色质(Chromatin);RNA, 反义(RNA, Antisense);基因表达调控(Gene Expression Regulation)

DOI 10.1038/s41594-022-00855-y

PMID 36369346

发布时间 2024-05-04

基金项目

R01 GM121613/GM/NIGMS NIH HHS/United States T32 HL007439/HL/NHLBI NIH HHS/United States R01 DK058044/DK/NIDDK NIH HHS/United States R24 DK106766/DK/NIDDK NIH HHS/United States U01 DK127405/DK/NIDDK NIH HHS/United States

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