Rnf20 inhibition enhances immunotherapy by improving regulatory T cell generation.

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作者： Xiangqian,Luo ^[1] ; Lihua,Mo ^[1] ; Xinxin,Wang ^[2] ; Shuang,Zhang ^[2] ; Huazhen,Liu ^[2] ; Gaohui,Wu ^[3] ; Qinmiao,Huang ^[4] ; Dabo,Liu ^[5] ; Pingchang,Yang ^[6]

作者单位： Department of Pediatric Otolaryngology, Shenzhen Hospital, Southern Medial University, 1333 Xinhu Road, Shenzhen, 518055, China. ^[1] Guangdong Provincial Regional Disease Key Laboratory, Room A7-509, 1066 Xueyuan Blvd, Shenzhen, 518055, China.;Institute of Allergy, State Key Laboratory of Respiratory Diseases Allergy Division, Immunology of Shenzhen University, Shenzhen University, Room A7-509, 1066 Xueyuan Blvd, Shenzhen, 518055, China. ^[2] Department of Respirology, Third Affiliated Hospital of Shenzhen University, Room A7-509, 1066 Xueyuan Blvd, Shenzhen, 518055, China. ^[3] Department of Respirology, Third Affiliated Hospital of Shenzhen University, Room A7-509, 1066 Xueyuan Blvd, Shenzhen, 518055, China. hqmwwb@163.com. ^[4] Department of Pediatric Otolaryngology, Shenzhen Hospital, Southern Medial University, 1333 Xinhu Road, Shenzhen, 518055, China. dbliu@126.com. ^[5] Guangdong Provincial Regional Disease Key Laboratory, Room A7-509, 1066 Xueyuan Blvd, Shenzhen, 518055, China. pcy2356@szu.edu.cn.;Institute of Allergy, State Key Laboratory of Respiratory Diseases Allergy Division, Immunology of Shenzhen University, Shenzhen University, Room A7-509, 1066 Xueyuan Blvd, Shenzhen, 518055, China. pcy2356@szu.edu.cn. ^[6]

关键词 Allergy CD4 T cell Endoplasmic reticulum stress Environmental pollutant Immune regulatory cell

主题词小鼠(Mice);动物(Animals);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);免疫疗法(Immunotherapy);卵白蛋白(Ovalbumin);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)

DOI 10.1007/s00018-022-04613-7

PMID 36371755

发布时间 2025-02-10

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