Leveraging a Dual Variable Domain Immunoglobulin to Create a Site-Specifically Modified Radioimmunoconjugate.

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作者： Douglas S,MacPherson ^[1] ; Dobeen,Hwang ^[2] ; Samantha M,Sarrett ^[3] ; Outi,Keinänen ^[4] ; Cindy,Rodriguez ^[5] ; Christoph,Rader ^[2] ; Brian M,Zeglis ^[6]

作者单位： Department of Chemistry, Hunter College of the City University of New York, 413 East 69th Street, New York, New York 10028, United States.;Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York 10016, United States.;Advanced Science Research Center (ASRC) at The Graduate Center, City University of New York, 85 St. Nicholas Terrace, New York, New York 10031, United States.;Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States. ^[1] Department of Immunology and Microbiology, UF Scripps Biomedical Research, University of Florida, Jupiter, Florida 33458, United States. ^[2] Department of Chemistry, Hunter College of the City University of New York, 413 East 69th Street, New York, New York 10028, United States.;Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York 10016, United States.;Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States. ^[3] Department of Chemistry, Hunter College of the City University of New York, 413 East 69th Street, New York, New York 10028, United States.;Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.;Department of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, Finland. ^[4] Department of Chemistry, Hunter College of the City University of New York, 413 East 69th Street, New York, New York 10028, United States.;Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.;Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York 10016, United States. ^[5] Department of Chemistry, Hunter College of the City University of New York, 413 East 69th Street, New York, New York 10028, United States.;Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York 10016, United States.;Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.;Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York 10016, United States.;Department of Radiology, Weill Cornell Medical College, 520 East 70th Street, New York, New York 10065, United States. ^[6]

关键词 177Lu HER2 catalytic antibody dual-variable domain antibody radioimmunotherapy site-selective bioconjugation site-specific bioconjugation targeted radionuclide therapy