Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice.

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作者： Alexander,Muik ^[1] ; Bonny Gaby,Lui ^[1] ; Maren,Bacher ^[1] ; Ann-Kathrin,Wallisch ^[1] ; Aras,Toker ^[1] ; Carla Iris Cadima,Couto ^[1] ; Alptekin,Güler ^[1] ; Veena,Mampilli ^[1] ; Geneva J,Schmitt ^[1] ; Jonathan,Mottl ^[1] ; Thomas,Ziegenhals ^[1] ; Stephanie,Fesser ^[1] ; Jonas,Reinholz ^[1] ; Florian,Wernig ^[1] ; Karla-Gerlinde,Schraut ^[1] ; Hossam,Hefesha ^[1] ; Hui,Cai ^[2] ; Qi,Yang ^[2] ; Kerstin C,Walzer ^[1] ; Jessica,Grosser ^[1] ; Stefan,Strauss ^[1] ; Andrew,Finlayson ^[1] ; Kimberly,Krüger ^[1] ; Orkun,Ozhelvaci ^[1] ; Katharina,Grikscheit ^[3] ; Niko,Kohmer ^[3] ; Sandra,Ciesek ^[3] ; Kena A,Swanson ^[4] ; Annette B,Vogel ^[2] ; Özlem,Türeci ^[1] ; Ugur,Sahin ^[1]

作者单位： BioNTech, An der Goldgrube 12, 55131 Mainz, Germany. ^[1] Pfizer, 401 N. Middletown Rd., Pearl River, NY 10960, USA. ^[2] Institute for Medical Virology, University Hospital, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany. ^[3] DZIF-German Centre for Infection Research, External Partner Site, 60596 Frankfurt am Main, Germany. ^[4] HI-TRON (Helmholtz Institute for Translational Oncology) Mainz by DKFZ, Obere Zahlbacherstr. 63, 55131 Mainz, Germany. ^[5] TRON gGmbH-Translational Oncology at the University Medical Center of the Johannes Gutenberg University, Freiligrathstraße 12, 55131 Mainz, Germany. ^[6]

主题词人类(Humans);动物(Animals);小鼠(Mice);疫苗(Vaccines);抗体, 中和(Antibodies, Neutralizing);RNA, 信使(RNA, Messenger)

DOI 10.1126/sciimmunol.ade9888

PMID 36378074

发布时间 2023-01-10

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Science immunology

2022年7卷78期

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Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice.

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Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice.

Science immunology

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