首页> Lung cancer (Amsterdam, Netherlands)> A high number of co-occurring genomic alterations detected by NGS is associated with worse clinical outcomes in advanced EGFR-mutant lung adenocarcinoma: Data from LATAM population.

A high number of co-occurring genomic alterations detected by NGS is associated with worse clinical outcomes in advanced EGFR-mutant lung adenocarcinoma: Data from LATAM population.

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第一作者： David,Heredia

第一单位： Department of Thoracic Oncology, Instituto Nacional de Cancerología (INCan), Mexico City, México.

作者： David,Heredia ^[1] ; Luis,Mas ^[2] ; Andres F,Cardona ^[3] ; Víctor,Oyervides ^[4] ; Rodrigo,Motta Guerrero ^[5] ; Marco,Galvez-Nino ^[2] ; Luis,Lara-Mejía ^[1] ; Carlos,Aliaga-Macha ^[5] ; Carlos,Carracedo ^[5] ; Edgar,Varela-Santoyo ^[1] ; Maritza,Ramos-Ramírez ^[1] ; David,Davila-Dupont ^[1] ; Juan,Martínez ^[4] ; Graciela,Cruz-Rico ^[1] ; Jordi,Remon ^[6] ; Oscar,Arrieta ^[7]

作者单位： Department of Thoracic Oncology, Instituto Nacional de Cancerología (INCan), Mexico City, México. ^[1] Medical Oncology Unit, Instituto Nacional de Enfermedades Neoplásicas (INEN), Lima, Perú. ^[2] Direction of Research, Science and Education, Luis Carlos Sarmiento Angulo Cancer Treatment and Research Center (CTIC), Bogota, Colombia. ^[3] Lung Tumours Unit, Centro Universitario Contra el Cáncer Hospital Universitario "Dr. José Eleuterio González" Monterrey, Nuevo León, México. ^[4] Clinical Oncology Department, Centro Oncológico Aliada, Lima, Perú. ^[5] Department of Medical Oncology, Centro Integral Oncológico Clara Campal (HM-CIOCC), Hospital HM Delfos, HM Hospitales, Barcelona, Spain. ^[6] Department of Thoracic Oncology, Instituto Nacional de Cancerología (INCan), Mexico City, México. Electronic address: ogarrieta@gmail.com. ^[7]

关键词 EGFR mutation Next-generation sequencing Non-small cell lung cancer TP53

医学主题词人类(Humans);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);高通量核苷酸序列分析(High-Throughput Nucleotide Sequencing);肺肿瘤(Lung Neoplasms);突变(Mutation);蛋白激酶抑制剂(Protein Kinase Inhibitors);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)

DOI 10.1016/j.lungcan.2022.11.002

PMID 36379126

发布时间 2022-12-23

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