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Associations of HLA and drug-metabolizing enzyme genes in co-trimoxazole-induced severe cutaneous adverse reactions.

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第一作者： Nontaya,Nakkam

第一单位： Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

作者： Nontaya,Nakkam ^[1] ; Niwat,Saksit ^[2] ; Parinya,Konyoung ^[3] ; Warayuwadee,Amornpinyo ^[4] ; Usanee,Khunarkornsiri ^[3] ; Danklai,Purimart ^[3] ; Oranuch,Pattanacheewapull ^[5] ; Tanaporn,Naewla ^[1] ; Pansakon,Wattanachai ^[1] ; Kanyarat,Khaeso ^[1] ; Pansu,Chumworathayi ^[6] ; Wichittra,Tassaneeyakul ^[7]

作者单位： Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. ^[1] Unit of Excellence on Pharmacogenomic Pharmacokinetic and Pharmacotherapeutic Researches (UPPER), School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand. ^[2] Pharmacy Unit, Udon Thani Hospital, Udon Thani, Thailand. ^[3] Division of Dermatology, Department of Internal Medicine, Khon Kaen Hospital, Khon Kaen, Thailand. ^[4] Pharmacy Department, Khon Kaen Hospital, Khon Kaen, Thailand. ^[5] Pharmacy Unit, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. ^[6] Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. Electronic address: wichitt@kku.ac.th. ^[7]

关键词 Co-trimoxazole DRESS Drug-metabolizing enzymes HLA SCARs SJS/TEN Severe cutaneous adverse reactions

医学主题词人类(Humans);等位基因(Alleles);抗惊厥药(Anticonvulsants);HLA-B抗原(HLA-B Antigens);多态现象, 遗传(Polymorphism, Genetic);Stevens-Johnson综合征(Stevens-Johnson Syndrome)

DOI 10.1016/j.dmpk.2022.100480

PMID 36379177

发布时间 2022-12-06

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