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Individualized Patient Care Through Model-Informed Precision Dosing: Reflections on Training Future Practitioners.

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第一作者： Roger,Jelliffe

第一单位： Laboratory of Applied Pharmacokinetics and Bioinformatics, University of Southern California School of Medicine, Children's Hospital of Los Angeles, 4650 Sunset Boulevard, #51, Los Angeles, California, 90027, USA.

作者： Roger,Jelliffe ^[1] ; Jiang,Liu ^[2] ; George L,Drusano ^[3] ; Marilyn N,Martinez ^[4]

作者单位： Laboratory of Applied Pharmacokinetics and Bioinformatics, University of Southern California School of Medicine, Children's Hospital of Los Angeles, 4650 Sunset Boulevard, #51, Los Angeles, California, 90027, USA. ^[1] Division of Pharmacometrics, Office of Clinical Pharmacology, Center for Drug Evaluation and Research (CDER), FDA, Silver Spring, Maryland, 20993, USA. ^[2] Institute for Therapeutic Innovation, College of Medicine, University of Florida, Lake Nona, Florida, 32827, USA. ^[3] Office of New Animal Drugs, Center for Veterinary Medicine (CVM), US Food and Drug Administration (FDA), Rockville, Maryland, 20855, USA. marilyn.martinez@fda.hhs.gov. ^[4]

关键词 Clinical pharmacokinetics Individual dose optimization Interacting Multiple Model approach Maximum likelihood estimation Nonparametric models

医学主题词人类(Humans);药物监测(Drug Monitoring);病人医疗护理(Patient Care);模型, 生物学(Models, Biological);教育, 药学(Education, Pharmacy);教育, 医学(Education, Medical)

DOI 10.1208/s12248-022-00769-z

PMID 36380020

发布时间 2023-01-17

基金项目

R01 GM068968/GM/NIGMS NIH HHS/United States R01 HD070886/HD/NICHD NIH HHS/United States R01 EB005803/EB/NIBIB NIH HHS/United States R01 GM065619/GM/NIGMS NIH HHS/United States

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