Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model.

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作者： David,Falck ^[1] ; Martin,Lechmann ^[2] ; Ana,Momčilović ^[1] ; Marco,Thomann ^[3] ; Carolien A M,Koeleman ^[1] ; Cordula,Jany ^[2] ; Sebastian,Malik ^[3] ; Manfred,Wuhrer ^[1] ; Dietmar,Reusch ^[3]

作者单位： Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands. ^[1] Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Munich, Penzberg, Germany. ^[2] Pharma Technical Development Europe, Roche Diagnostics GmbH, Penzberg, Germany. ^[3]

关键词 N-glycosylation Pharmacokinetics glycoengineering liquid chromatography – mass spectrometry minipig monoclonal antibodies subcutaneous injection

主题词动物(Animals);猪(Swine);注射, 静脉内(Injections, Intravenous);猪, 雏型(Swine, Miniature);免疫球蛋白G(Immunoglobulin G);抗体, 单克隆(Antibodies, Monoclonal);糖基化(Glycosylation);注射, 皮下(Injections, Subcutaneous)

DOI 10.1080/19420862.2022.2145929

PMID 36383465

发布时间 2023-02-08

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Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model.

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Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model.

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