Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset.

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第一作者： Xiang,Shi

第一单位： State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

作者： Xiang,Shi ^[1] ; Yanrong,Zhuang ^[2] ; Zhenhua,Chen ^[3] ; Mingrui,Xu ^[1] ; Junqi,Kuang ^[2] ; Xue-Lian,Sun ^[1] ; Lisen,Gao ^[2] ; Xia,Kuang ^[2] ; Huairen,Zhang ^[4] ; Wei,Li ^[1] ; Samuel Zheng Hao,Wong ^[2] ; Chuanyu,Liu ^[1] ; Longqi,Liu ^[2] ; Danhua,Jiang ^[1] ; Duanqing,Pei ^[1] ; Yi,Lin ^[1] ; Qing-Feng,Wu ^[2]

作者单位： State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. ^[1] University of Chinese Academy of Sciences, Beijing 100101, China. ^[2] IDG/McGovern Institute for Brain Research, Tsinghua-Peking Joint Centre for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China. ^[3] CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. ^[4] Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA. ^[5] BGI-ShenZhen, Shenzhen 518103, China. ^[6] Shenzhen Bay Laboratory, Shenzhen 518000, China. ^[7] BGI College and Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450000, China. ^[8] Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou 310024, China. ^[9] Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing 100101, China. ^[10] Chinese Institute for Brain Research, Beijing 102206, China. ^[11] Beijing Children's Hospital, Capital Medical University, Beijing 100045, China. ^[12]

主题词人类(Humans);细胞谱系(Cell Lineage);下丘脑(Hypothalamus);神经元(Neurons);神经肽类(Neuropeptides);青春期(Puberty);T盒域蛋白质类(T-Box Domain Proteins);动物(Animals);小鼠(Mice)

DOI 10.1126/sciadv.abq2987

PMID 36383654

发布时间 2023-04-05

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Science advances

2022年8卷46期

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Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset.

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Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset.

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