Ketogenic diet containing medium-chain triglyceride ameliorates transcriptome disruption in skeletal muscles of rat models of duchenne muscular dystrophy.

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作者： Yuri,Fujikura ^[1] ; Keitaro,Yamanouchi ^[2] ; Hidetoshi,Sugihara ^[2] ; Masaki,Hatakeyama ^[3] ; Tomoki,Abe ^[1] ; Satoru,Ato ^[1] ; Katsutaka,Oishi ^[4]

作者单位： Healthy Food Science Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, 305-8566, Japan. ^[1] Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8657, Japan. ^[2] Miyagi Health Innovation, Sendai, Miyagi, 980-0021, Japan. ^[3] Japan Society for the Promotion of Science, Tokyo, Japan. ^[4] Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Chiba, Noda, Japan. ^[5] Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Kashiwa, Japan. ^[6] School of Integrative and Global Majors (SIGMA), University of Tsukuba, Tsukuba, Ibaraki, Japan. ^[7]

关键词 DAPC, dystrophin-associated glycoprotein complex DEG, differentially expressed gene DMD, Duchenne muscular dystrophy Duchenne muscular dystrophy FPKM, fragments per kilobase of exons per million mapped reads GO, gene ontology KD, ketogenic diet KR, ketogenic ratio Ketogenic diet Ketone bodies MCT, medium-chain triglycerides MCTKD, medium-chain triglycerides containing ketogenic diet ND, normal diet PC, principal component SERCA, sarco/endoplasmic reticulum (SR) Ca2+ ATPase Skeletal muscle TA, tibialis anterior Transcriptome WT, wild type

DOI 10.1016/j.bbrep.2022.101378

PMID 36386439

发布时间 2022-11-18

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Biochemistry and biophysics reports

2022年32卷

101378页

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Ketogenic diet containing medium-chain triglyceride ameliorates transcriptome disruption in skeletal muscles of rat models of duchenne muscular dystrophy.

Biochemistry and biophysics reports

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Biochemistry and biophysics reports

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Ketogenic diet containing medium-chain triglyceride ameliorates transcriptome disruption in skeletal muscles of rat models of duchenne muscular dystrophy.

Biochemistry and biophysics reports

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Biochemistry and biophysics reports

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