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Uncovering novel mutational signatures by <i>de novo</i> extraction with SigProfilerExtractor.

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第一作者： S M Ashiqul,Islam

第一单位： Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.;Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA.;Moores Cancer Center, UC San Diego, La Jolla, CA 92037, USA.

作者： S M Ashiqul,Islam ^[1] ; Marcos,Díaz-Gay ^[1] ; Yang,Wu ^[2] ; Mark,Barnes ^[1] ; Raviteja,Vangara ^[1] ; Erik N,Bergstrom ^[1] ; Yudou,He ^[1] ; Mike,Vella ^[3] ; Jingwei,Wang ^[4] ; Jon W,Teague ^[4] ; Peter,Clapham ^[4] ; Sarah,Moody ^[4] ; Sergey,Senkin ^[5] ; Yun Rose,Li ^[6] ; Laura,Riva ^[4] ; Tongwu,Zhang ^[7] ; Andreas J,Gruber ^[8] ; Christopher D,Steele ^[9] ; Burçak,Otlu ^[1] ; Azhar,Khandekar ^[1] ; Ammal,Abbasi ^[1] ; Laura,Humphreys ^[4] ; Natalia,Syulyukina ^[10] ; Samuel W,Brady ^[11] ; Boian S,Alexandrov ^[12] ; Nischalan,Pillay ^[13] ; Jinghui,Zhang ^[11] ; David J,Adams ^[4] ; Iñigo,Martincorena ^[4] ; David C,Wedge ^[14] ; Maria Teresa,Landi ^[7] ; Paul,Brennan ^[5] ; Michael R,Stratton ^[4] ; Steven G,Rozen ^[2] ; Ludmil B,Alexandrov ^[1]

作者单位： Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.;Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA.;Moores Cancer Center, UC San Diego, La Jolla, CA 92037, USA. ^[1] Centre for Computational Biology and Programme in Cancer & Stem Cell Biology, Duke NUS Medical School, Singapore 169857, Singapore. ^[2] NVIDIA Corporation, 2788 San Tomas Expressway, Santa Clara, CA 95051, USA. ^[3] Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK. ^[4] Genetic Epidemiology Group, International Agency for Research on Cancer, Cedex 08, 69372 Lyon, France. ^[5] Departments of Radiation Oncology and Cancer Genetics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. ^[6] Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. ^[7] Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LF, UK.;Manchester Cancer Research Centre, The University of Manchester, Manchester M20 4GJ, UK.;Department of Biology, University of Konstanz, Universitaetsstrasse 10, D-78464 Konstanz, Germany. ^[8] Research Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK. ^[9] Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA. ^[10] Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. ^[11] Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. ^[12] Research Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK.;Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK. ^[13] Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LF, UK.;Manchester Cancer Research Centre, The University of Manchester, Manchester M20 4GJ, UK. ^[14]

关键词 cancer genomics genomics mutagenesis mutational signatures

DOI 10.1016/j.xgen.2022.100179

PMID 36388765

发布时间 2026-03-11

基金项目

MR/V000292/1/MRC_/Medical Research Council/United Kingdom 21777/CRUK_/Cancer Research UK/United Kingdom F32 CA232635/CA/NCI NIH HHS/United States R01 ES032547/ES/NIEHS NIH HHS/United States R01 CA269919/CA/NCI NIH HHS/United States K12 CA001727/CA/NCI NIH HHS/United States 001/WHO_/World Health Organization/International

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Uncovering novel mutational signatures by <i>de novo</i> extraction with SigProfilerExtractor.

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Uncovering novel mutational signatures by <i>de novo</i> extraction with SigProfilerExtractor.

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