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Pan-neutralizing, germline-encoded antibodies against SARS-CoV-2: Addressing the long-term problem of escape variants.

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第一作者： Justin Mark,Lunderberg

第一单位： Center for Inflammation Research, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

作者： Justin Mark,Lunderberg ^[1] ; Sanjucta,Dutta ^[2] ; Ai-Ris Y,Collier ^[3] ; Jeng-Shin,Lee ^[4] ; Yen-Ming,Hsu ^[4] ; Qiao,Wang ^[5] ; Weina,Zheng ^[5] ; Shushun,Hao ^[5] ; Haohai,Zhang ^[1] ; Lili,Feng ^[6] ; Simon C,Robson ^[1] ; Wenda,Gao ^[7] ; Stefan,Riedel ^[2]

作者单位： Center for Inflammation Research, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. ^[1] Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. ^[2] Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. ^[3] AB Biosciences, Inc., Concord, MA, United States. ^[4] Shijiazhuang Hipro Biotechnology Co., Ltd., Hebei, China. ^[5] Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. ^[6] Antagen Diagnostics, Inc., Canton, MA, United States.;Antagen Pharmaceuticals, Inc., Canton, MA, United States. ^[7]

关键词 B cell memory B-1 B cells IgM Reverse Vaccinology SARS-CoV-2 neutralizing antibodies somatic hypermutation vaccines

医学主题词人类(Humans);中和试验(Neutralization Tests);抗体, 中和(Antibodies, Neutralizing);免疫球蛋白G(Immunoglobulin G);生殖细胞(Germ Cells);免疫球蛋白M(Immunoglobulin M)

DOI 10.3389/fimmu.2022.1032574

PMID 36389829

发布时间 2022-11-22

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