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LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.

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作者单位: Department Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany. [1] Department Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany. [2] Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V, Dortmund, Germany. [3] Department of Biomedical Sciences, University of Padua, Padua, Italy. [4] Faculty of Medicine, Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany. [5] Institute for Integrative Cell Biology and Physiology, Faculty of Biology, University of Münster, Münster, Germany. [6] Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany. [7] Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. [8] Neuroscience PhD Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA. [9] Proteomics of Cellular Signaling, Department of Infection and Immunity, Luxembourg Institute of Health, Strassen, Luxembourg. [10] Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany. [11] Medical Proteome Analysis, Center for Protein Diagnostics (PRODI), Ruhr-University Bochum, Bochum, Germany. [12] Department of Life Sciences and Medicine, University of Luxembourg, Belvaux, Luxembourg. [13] Laboratory for Electron Microscopy, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. [14] Department of Biology, University of Padua, Padua, Italy. [15] Centro Studi per la Neurodegenerazione (CESNE), University of Padova, Padua, Italy. [16] RESOLV Cluster of Excellence, Ruhr University Bochum, Bochum, Germany. [17] Padua Neuroscience Center (PNC), University of Padua, Padua, Italy. [18]
DOI 10.15252/embj.2022112006
PMID 36398858
发布时间 2024-07-07
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