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A randomized phase 2 trial of nintedanib and low-dose cytarabine in elderly patients with acute myeloid leukemia ineligible for intensive chemotherapy.

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第一作者： Andrew F,Berdel

第一单位： Department of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.

作者： Andrew F,Berdel ^[1] ; Raphael,Koch ^[2] ; Joachim,Gerss ^[2] ; Marcus,Hentrich ^[3] ; Rudolf,Peceny ^[4] ; Tobias,Bartscht ^[5] ; Björn,Steffen ^[6] ; Marina,Bischoff ^[7] ; Karsten,Spiekermann ^[8] ; Linus,Angenendt ^[1] ; Jan-Henrik,Mikesch ^[1] ; Tobias,Kewitz ^[9] ; Trude,Butterfass-Bahloul ^[9] ; Hubert,Serve ^[6] ; Georg,Lenz ^[1] ; Wolfgang E,Berdel ^[1] ; Utz,Krug ^[10] ; Christoph,Schliemann ^[11]

作者单位： Department of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany. ^[1] Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany. ^[2] Department of Hematology and Oncology, Red Cross Hospital, Munich, Germany. ^[3] Department of Oncology, Hematology and Stem Cell Transplantation, Klinikum Osnabrück, Osnabrück, Germany. ^[4] Department of Medicine I, University Hospital Lübeck, Lübeck, Germany. ^[5] Department of Medicine II, University Hospital Frankfurt, Frankfurt, Germany. ^[6] Department of Hematology and Oncology, Klinikum Idar-Oberstein, Idar-Oberstein, Germany. ^[7] Department of Medicine III, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany. ^[8] Centre for Clinical Trials, University of Münster, Münster, Germany. ^[9] Department of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.;Department of Medicine, III, Hospital Leverkusen, Leverkusen, Germany. ^[10] Department of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany. christoph.schliemann@ukmuenster.de. ^[11]

关键词 Acute myeloid leukemia Angiogenesis Low-dose cytarabine Nintedanib

医学主题词人类(Humans);老年人(Aged);老年人, 80以上(Aged, 80 and over);阿糖胞苷(Cytarabine);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);吲哚类(Indoles)

DOI 10.1007/s00277-022-05025-0

PMID 36399194

发布时间 2023-04-26

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