Host metabolome predicts the severity and onset of acute toxicities induced by CAR T-cell therapy.

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作者： Akansha,Jalota ^[1] ; Courtney E,Hershberger ^[2] ; Manishkumar S,Patel ^[1] ; Agrima,Mian ^[3] ; Aiman,Faruqi ^[4] ; Gholamreza,Khademi ^[2] ; Daniel M,Rotroff ^[2] ; Brian T,Hill ^[4] ; Neetu,Gupta ^[4]

作者单位： Department of Inflammation and Immunity, Lerner Research Institute, Cleveland, OH. ^[1] Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland, OH. ^[2] Department of Internal Medicine, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH. ^[3] Cleveland Clinic Lerner College of Medicine, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH. ^[4] Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH. ^[5]

主题词人类(Humans);免疫疗法, 过继(Immunotherapy, Adoptive);代谢组(Metabolome);代谢组学(Metabolomics);衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);抗原, CD19(Antigens, CD19)

DOI 10.1182/bloodadvances.2022007456

PMID 36399526

发布时间 2024-04-03

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Blood advances

2023年7卷17期

4690-4700页

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Host metabolome predicts the severity and onset of acute toxicities induced by CAR T-cell therapy.

Blood advances

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Host metabolome predicts the severity and onset of acute toxicities induced by CAR T-cell therapy.

Blood advances

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Blood advances

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