High-sensitivity and high-resolution therapeutic antibody charge variant and impurity characterization by microfluidic native capillary electrophoresis-mass spectrometry.

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第一作者： Zhijie,Wu

第一单位： Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.

作者： Zhijie,Wu ^[1] ; Hongxia,Wang ^[2] ; Jikang,Wu ^[1] ; Yu,Huang ^[1] ; Xueqing,Zhao ^[1] ; Jennifer B,Nguyen ^[3] ; Michael P,Rosconi ^[3] ; Erica A,Pyles ^[3] ; Haibo,Qiu ^[4] ; Ning,Li ^[1]

作者单位： Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA. ^[1] Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA. Electronic address: wang_hongx@hotmail.com. ^[2] Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA. ^[3] Analytical Chemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA. Electronic address: haibo.qiu@regeneron.com. ^[4]

关键词 Charge variant analysis Mass spectrometry Microfluidic capillary electrophoresis Monoclonal antibody Native intact analysis Post-translational modifications

主题词微流体学(Microfluidics);电泳, 毛细管(Electrophoresis, Capillary);质谱分析法(Mass Spectrometry);等电聚焦(Isoelectric Focusing);抗体, 单克隆(Antibodies, Monoclonal)

DOI 10.1016/j.jpba.2022.115147

PMID 36399907

发布时间 2022-11-29

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