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Thiadiazine-thione derivatives ameliorate STZ-induced diabetic neuropathy by regulating insulin and neuroinflammatory signaling.

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第一作者： Sonia,Qureshi

第一单位： Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan; Krembil Research Institute, University Health Network, M5G 1L7, Toronto, Ontario, Canada.

作者： Sonia,Qureshi ^[1] ; Gowhar,Ali ^[2] ; Tahir,Muhammad ^[3] ; Muhammad,Idrees ^[4] ; Sultan,Ullah ^[5] ; Salman,Ali Khan ^[6] ; Rahim,Ullah ^[7] ; Rasool,Khan ^[8] ; Zaheer,Ul-Haq ^[9] ; Abdul,Haseeb Mohsin ^[8] ; Il-Keun,Kong ^[10]

作者单位： Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan; Krembil Research Institute, University Health Network, M5G 1L7, Toronto, Ontario, Canada. ^[1] Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan. Electronic address: gowhar_ali@uop.edu.pk. ^[2] Molecular Neuropsychiatry and Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. ^[3] Division of Applied Life Science (BK21 Four), Gyeongsang National University, Jinju 52828, Gyeongnam Province, Republic of Korea; Institute of Agriculture and Life Science, Gyeongsang National University, Gyeongnam Province, Republic of Korea. ^[4] Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, 33458, USA. ^[5] H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan. ^[6] Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan. ^[7] Institute of chemical sciences, University of Peshawar, Peshawar, Pakistan. ^[8] Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan; Institute of chemical sciences, University of Peshawar, Peshawar, Pakistan. ^[9] Division of Applied Life Science (BK21 Four), Gyeongsang National University, Jinju 52828, Gyeongnam Province, Republic of Korea; Institute of Agriculture and Life Science, Gyeongsang National University, Gyeongnam Province, Republic of Korea; The Kingkong Co. Ltd., Gyeongsang National University, Jinju 52828, Gyeongnam Province, Republic of Korea. ^[10]

关键词 Diabetic neuropathy Insulin receptor substrate (IRS)Neuroinflammation PI3KT/AKT Thiadiazine-Thione