Development of an oral mucosal irritation test using a three-dimensional human buccal oral mucosal model.

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作者： Seiya,Aizawa ^[1] ; Hidenori,Yoshida ^[2] ; Kazuhiko,Umeshita ^[3] ; Shinichi,Watanabe ^[4] ; Yutaka,Takahashi ^[2] ; Shinji,Sakane ^[3] ; Hitoshi,Sakaguchi ^[2] ; Shinsuke,Kataoka ^[4]

作者单位： Safety Science Research Laboratories, LION Corporation, Kanagawa, Japan. Electronic address: s-aizawa@lion.co.jp. ^[1] Safety Science Research Laboratories, Kao Corporation, Tochigi, Japan. ^[2] Safety & Analysis, R&D Support, Sunstar Inc., Osaka, Japan. ^[3] Safety Science Research Laboratories, LION Corporation, Kanagawa, Japan. ^[4]

关键词 Alternative test method EpiOral Oral mucosal irritation Three-dimensional cultured oral model

主题词动物(Animals);人类(Humans);结果可重复性(Reproducibility of Results);口腔黏膜(Mouth Mucosa);动物替代试验(Animal Testing Alternatives);刺激剂(Irritants);实验室(Laboratories)

DOI 10.1016/j.tiv.2022.105519

PMID 36403724

发布时间 2023-01-03

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