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SV-AUC as a stability-indicating method for the characterization of mRNA-LNPs.

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第一作者： Anian,Thaller

第一单位： Coriolis Pharma, Fraunhoferstraße 18 B, 82152 Martinsried, Germany; Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet München, Butenandtstrasse 5, 81377 Munich, Germany.

作者： Anian,Thaller ^[1] ; Lukas,Schmauder ^[2] ; Wolfgang,Frieß ^[3] ; Gerhard,Winter ^[3] ; Tim,Menzen ^[2] ; Andrea,Hawe ^[2] ; Klaus,Richter ^[4]

作者单位： Coriolis Pharma, Fraunhoferstraße 18 B, 82152 Martinsried, Germany; Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet München, Butenandtstrasse 5, 81377 Munich, Germany. ^[1] Coriolis Pharma, Fraunhoferstraße 18 B, 82152 Martinsried, Germany. ^[2] Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet München, Butenandtstrasse 5, 81377 Munich, Germany. ^[3] Coriolis Pharma, Fraunhoferstraße 18 B, 82152 Martinsried, Germany. Electronic address: Klaus.Richter@coriolis-pharma.com. ^[4]

关键词 Analytical ultracentrifugation Dynamic light scattering Flotation Lipid nanoparticle Nanoparticle density Particle size distribution Vaccines

医学主题词人类(Humans);RNA, 信使(RNA, Messenger);曲线下面积(Area Under Curve);RNA, 病毒(RNA, Viral);纳米粒子(Nanoparticles);超速离心法(Ultracentrifugation)

DOI 10.1016/j.ejpb.2022.11.014

PMID 36410586

发布时间 2023-01-20

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